Chitosan preparations for wounds and burns: Antimicrobial and wound-healing effects

Tianhong Dai, Masamitsu Tanaka, Ying Ying Huang, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

758 Citations (Scopus)

Abstract

Since its discovery approximately 200 years ago, chitosan, as a cationic natural polymer, has been widely used as a topical dressing in wound management owing to its hemostatic, stimulation of healing, antimicrobial, nontoxic, biocompatible and biodegradable properties. This article covers the antimicrobial and wound-healing effects of chitosan, as well as its derivatives and complexes, and its use as a vehicle to deliver biopharmaceuticals, antimicrobials and growth factors into tissue. Studies covering applications of chitosan in wounds and burns can be classified into in vitro, animal and clinical studies. Chitosan preparations are classified into native chitosan, chitosan formulations, complexes and derivatives with other substances. Chitosan can be used to prevent or treat wound and burn infections not only because of its intrinsic antimicrobial properties, but also by virtue of its ability to deliver extrinsic antimicrobial agents to wounds and burns. It can also be used as a slow-release drug-delivery vehicle for growth factors to improve wound healing. The large number of publications in this area suggests that chitosan will continue to be an important agent in the management of wounds and burns.

Original languageEnglish
Pages (from-to)857-879
Number of pages23
JournalExpert Review of Anti-Infective Therapy
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

Keywords

  • antimicrobial activity
  • chitin
  • chitosan
  • drug delivery
  • wound dressing
  • wound healing
  • wound infection

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Fingerprint

Dive into the research topics of 'Chitosan preparations for wounds and burns: Antimicrobial and wound-healing effects'. Together they form a unique fingerprint.

Cite this