Chemical composition and anti-inflammatory activities of the essential oils from Acacia mearnsii de Wild

Opeyemi N. Avoseh, Ope Oluwa O. Oyedeji, Kayode Aremu, Benedicta N. Nkeh-Chungag, Sandile P. Songca, Samuel O. Oluwafemi, Adebola O. Oyedeji

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The volatile oils of the leaves and the stem bark of Acacia mearnsii de Wild obtained by hydro-distillation were analysed by gas chromatography-mass spectrometry. A total of 20, 38, 29 and 38 components accounted for 93.8%, 92.1%, 78.5% and 90.9% of the total oils of the fresh, dry leaves and fresh, dry stem bark, respectively. The major components of the oil were octadecyl alcohol (25.5%) and phytol (10.5%); cis-verbenol (29.5%); phytol (10.1%) and phytol (23.4%) for the fresh leaves, dried leaves, fresh stem, dry stem bark, respectively. Oral administration of essential oils at a dose of 2% showed significant (p < 0.05) anti-inflammatory properties in the albumin-induced test model in rats. Oils from the fresh leaves and dry stems inhibited inflammation beyond 4 h post treatment. The potent anti-inflammatory activity of essential oils of A. mearnsii hereby confirmed its traditional use in treating various inflammatory diseases.

Original languageEnglish
Pages (from-to)1184-1188
Number of pages5
JournalNatural Product Research
Volume29
Issue number12
DOIs
Publication statusPublished - 18 Jun 2015
Externally publishedYes

Keywords

  • Acacia mearnsii
  • cis-verbenol
  • egg albumin-induced oedema
  • essential oils
  • inflammation
  • phytol

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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