Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

Sahan C.B. Herath; Yue Du; Dong an Wang; Kin Liao; Qingguo Wang; Harry Asada; Peter C.Y. Chen

doi:10.1016/j.jmbbm.2013.11.012

Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

Sahan C.B. Herath, Yue Du, Dong an Wang, Kin Liao, Qingguo Wang, Harry Asada, Peter C.Y. Chen

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior.

Original language	English
Pages (from-to)	253-265
Number of pages	13
Journal	Journal of the Mechanical Behavior of Biomedical Materials
Volume	30
DOIs	https://doi.org/10.1016/j.jmbbm.2013.11.012
Publication status	Published - Feb 2014
Externally published	Yes

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Mechanics of Materials

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10.1016/j.jmbbm.2013.11.012

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Herath, S. C. B., Du, Y., Wang, D. A., Liao, K., Wang, Q., Asada, H., & Chen, P. C. Y. (2014). Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field. Journal of the Mechanical Behavior of Biomedical Materials, 30, 253-265. https://doi.org/10.1016/j.jmbbm.2013.11.012

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abstract = "In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior.",

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doi = "10.1016/j.jmbbm.2013.11.012",

language = "English",

volume = "30",

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Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field. / Herath, Sahan C.B.; Du, Yue; Wang, Dong an et al.
In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 30, 02.2014, p. 253-265.

Research output: Contribution to journal › Article › peer-review

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T1 - Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

AU - Herath, Sahan C.B.

AU - Du, Yue

AU - Wang, Dong an

AU - Liao, Kin

AU - Wang, Qingguo

AU - Asada, Harry

AU - Chen, Peter C.Y.

PY - 2014/2

Y1 - 2014/2

N2 - In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior.

AB - In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior.

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JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

ER -

Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

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