Cellulose-Based Nanofibril Composite Materials as a New Approach to Fight Bacterial Infections

Somaye Rashki, Neda Shakour, Zahra Yousefi, Marzieh Rezaei, Mina Homayoonfal, Ehsan Khabazian, Fatemeh Atyabi, Fatemeh Aslanbeigi, Rouzita Safaei Lapavandani, Samaneh Mazaheri, Michael R. Hamblin, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


Antibiotic resistant microorganisms have become an enormous global challenge, and are predicted to cause hundreds of millions of deaths. Therefore, the search for novel/alternative antimicrobial agents is a grand global challenge. Cellulose is an abundant biopolymer with the advantages of low cost, biodegradability, and biocompatibility. With the recent growth of nanotechnology and nanomedicine, numerous researchers have investigated nanofibril cellulose to try to develop an anti-bacterial biomaterial. However, nanofibril cellulose has no inherent antibacterial activity, and therefore cannot be used on its own. To empower cellulose with anti-bacterial properties, new efficient nanomaterials have been designed based on cellulose-based nanofibrils as potential wound dressings, food packaging, and for other antibacterial applications. In this review we summarize reports concerning the therapeutic potential of cellulose-based nanofibrils against various bacterial infections.

Original languageEnglish
Article number732461
JournalFrontiers in Bioengineering and Biotechnology
Publication statusPublished - 11 Nov 2021


  • antimicrobial activity
  • bacterial infections
  • cellulose
  • nanofibrils
  • nanotechnology

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Histology
  • Biomedical Engineering


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