Cell viability study of green synthesized CdTe/CdSe quantum dots against osteosarcoma cell line for improved therapeutic action

Ncapayi Vuyelwa; Oluwatobi S. Oluwafemi

doi:10.1557/mrc.2018.236

Cell viability study of green synthesized CdTe/CdSe quantum dots against osteosarcoma cell line for improved therapeutic action

Ncapayi Vuyelwa, Oluwatobi S. Oluwafemi

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

Abstract

LM-8 is a murine osteosarcoma cell line associated with bone tumor in young adult and children. It contains the nuclear factor-κB which make this cell high resistance to irradiation thus limiting its treatment only to chemotherapy and surgery which has become a source of concerned for cancer therapy. In addressing this problem, we herein report the synthesis of CdTe/CdSe core/shell quantum dots (QDs) via a simple, reproducible method and its cytotoxic action against the LM-8 cell line. The cell viability study shows that the as-synthesized QDs are toxic to the LM-8 cell line in a concentration- A nd time-dependent manner.

Original language	English
Pages (from-to)	340-343
Number of pages	4
Journal	MRS Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1557/mrc.2018.236
Publication status	Published - 1 Mar 2019

ASJC Scopus subject areas

General Materials Science

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10.1557/mrc.2018.236

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title = "Cell viability study of green synthesized CdTe/CdSe quantum dots against osteosarcoma cell line for improved therapeutic action",

abstract = "LM-8 is a murine osteosarcoma cell line associated with bone tumor in young adult and children. It contains the nuclear factor-κB which make this cell high resistance to irradiation thus limiting its treatment only to chemotherapy and surgery which has become a source of concerned for cancer therapy. In addressing this problem, we herein report the synthesis of CdTe/CdSe core/shell quantum dots (QDs) via a simple, reproducible method and its cytotoxic action against the LM-8 cell line. The cell viability study shows that the as-synthesized QDs are toxic to the LM-8 cell line in a concentration- A nd time-dependent manner.",

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N2 - LM-8 is a murine osteosarcoma cell line associated with bone tumor in young adult and children. It contains the nuclear factor-κB which make this cell high resistance to irradiation thus limiting its treatment only to chemotherapy and surgery which has become a source of concerned for cancer therapy. In addressing this problem, we herein report the synthesis of CdTe/CdSe core/shell quantum dots (QDs) via a simple, reproducible method and its cytotoxic action against the LM-8 cell line. The cell viability study shows that the as-synthesized QDs are toxic to the LM-8 cell line in a concentration- A nd time-dependent manner.

AB - LM-8 is a murine osteosarcoma cell line associated with bone tumor in young adult and children. It contains the nuclear factor-κB which make this cell high resistance to irradiation thus limiting its treatment only to chemotherapy and surgery which has become a source of concerned for cancer therapy. In addressing this problem, we herein report the synthesis of CdTe/CdSe core/shell quantum dots (QDs) via a simple, reproducible method and its cytotoxic action against the LM-8 cell line. The cell viability study shows that the as-synthesized QDs are toxic to the LM-8 cell line in a concentration- A nd time-dependent manner.

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Cell viability study of green synthesized CdTe/CdSe quantum dots against osteosarcoma cell line for improved therapeutic action

Abstract

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UN SDGs

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