TY - JOUR
T1 - Carbon nanotubes part II
T2 - A remarkable carrier for drug and gene delivery
AU - Karimi, Mahdi
AU - Solati, Navid
AU - Ghasemi, Amir
AU - Estiar, Mehrdad Asghari
AU - Hashemkhani, Mahshid
AU - Kiani, Parnian
AU - Mohamed, Elmira
AU - Saeidi, Ahad
AU - Taheri, Mahdiar
AU - Avci, Pinar
AU - Aref, Amir R.
AU - Amiri, Mohammad
AU - Baniasadi, Fazel
AU - Hamblin, Michael R.
N1 - Publisher Copyright:
© 2015 Informa UK, Ltd.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Introduction: Carbon nanotubes (CNT) have recently been studied as novel and versatile drug and gene delivery vehicles. When CNT are suitably functionalized, they can interact with various cell types and are taken up by endocytosis.Areas covered: Anti-cancer drugs cisplatin and doxorubicin have been delivered by CNT, as well as methotrexate, taxol and gemcitabine. The delivery of the antifungal compound amphotericin B and the oral administration of erythropoietin have both been assisted using CNT. Frequently, targeting moieties such as folic acid, epidermal growth factor or various antibodies are attached to the CNT-drug nanovehicle. Different kinds of functionalization (e.g., polycations) have been used to allow CNT to act as gene delivery vectors. Plasmid DNA, small interfering RNA and micro-RNA have all been delivered by CNT vehicles. Significant concerns are raised about the nanotoxicology of the CNT and their potentially damaging effects on the environment.Expert opinion: CNT-mediated drug delivery has been studied for over a decade, and both in vitro and in vivo studies have been reported. The future success of CNTs as vectors in vivo and in clinical application will depend on achievement of efficacious therapy with minimal adverse effects and avoidance of possible toxic and environmentally damaging effects.
AB - Introduction: Carbon nanotubes (CNT) have recently been studied as novel and versatile drug and gene delivery vehicles. When CNT are suitably functionalized, they can interact with various cell types and are taken up by endocytosis.Areas covered: Anti-cancer drugs cisplatin and doxorubicin have been delivered by CNT, as well as methotrexate, taxol and gemcitabine. The delivery of the antifungal compound amphotericin B and the oral administration of erythropoietin have both been assisted using CNT. Frequently, targeting moieties such as folic acid, epidermal growth factor or various antibodies are attached to the CNT-drug nanovehicle. Different kinds of functionalization (e.g., polycations) have been used to allow CNT to act as gene delivery vectors. Plasmid DNA, small interfering RNA and micro-RNA have all been delivered by CNT vehicles. Significant concerns are raised about the nanotoxicology of the CNT and their potentially damaging effects on the environment.Expert opinion: CNT-mediated drug delivery has been studied for over a decade, and both in vitro and in vivo studies have been reported. The future success of CNTs as vectors in vivo and in clinical application will depend on achievement of efficacious therapy with minimal adverse effects and avoidance of possible toxic and environmentally damaging effects.
KW - Biomolecule delivery
KW - Carbon nanotubes
KW - Drug delivery systems
KW - Gene delivery
KW - Toxicology
UR - http://www.scopus.com/inward/record.url?scp=84931589277&partnerID=8YFLogxK
U2 - 10.1517/17425247.2015.1004309
DO - 10.1517/17425247.2015.1004309
M3 - Review article
C2 - 25613837
AN - SCOPUS:84931589277
SN - 1742-5247
VL - 12
SP - 1089
EP - 1105
JO - Expert Opinion on Drug Delivery
JF - Expert Opinion on Drug Delivery
IS - 7
ER -