Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing

Sindi P. Ndlovu; Keolebogile S.C.M. Motaung; Mapula Razwinani; Sibusiso Alven; Samson A. Adeyemi; Philemon N. Ubanako; Lindokuhle M. Ngema; Thierry Y. Fonkui; Derek T. Ndinteh; Pradeep Kumar; Yahya E. Choonara; Blessing A. Aderibigbe

doi:10.3390/pharmaceutics16101313

Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing

Sindi P. Ndlovu, Keolebogile S.C.M. Motaung, Mapula Razwinani, Sibusiso Alven, Samson A. Adeyemi, Philemon N. Ubanako, Lindokuhle M. Ngema, Thierry Y. Fonkui, Derek T. Ndinteh, Pradeep Kumar, Yahya E. Choonara, Blessing A. Aderibigbe

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting method from a combination of polyvinyl alcohol (PVA), Pluronic F127 (PF127), and gum acacia. Results: The successful preparation of the membranes and loading of the extract were confirmed using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The prepared membranes were biodegradable and non-toxic to human skin cells (HaCaT), with high biocompatibility of 92 to 112% cell viability and good hemocompatibility with absorbance ranging from 0.17 to 0.30. The membrane’s highest water vapor transmission rate was 1654.7333 ± 0.736 g/m²/day and the highest % porosity was 76%. The membranes supported cellular adhesion and migration, with the highest closure being 68% after 4 days compared with the commercial wound dressings. This membrane exhibited enhanced antimicrobial activity against the pathogens responsible for wound infections. Conclusions: The distinct features of the membranes make them promising wound dressings for treating infected wounds.

Original language	English
Article number	1313
Journal	Pharmaceutics
Volume	16
Issue number	10
DOIs	https://doi.org/10.3390/pharmaceutics16101313
Publication status	Published - Oct 2024

Keywords

and membranes
Capparis sepiaria extract
chronic wounds
gum acacia
Pluronic F127
polyvinyl alcohol
propylene glycol
sodium alginate
wound dressing
wounds

ASJC Scopus subject areas

Pharmaceutical Science

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10.3390/pharmaceutics16101313

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Ndlovu, S. P., Motaung, K. S. C. M., Razwinani, M., Alven, S., Adeyemi, S. A., Ubanako, P. N., Ngema, L. M., Fonkui, T. Y., Ndinteh, D. T., Kumar, P., Choonara, Y. E., & Aderibigbe, B. A. (2024). Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing. Pharmaceutics, 16(10), Article 1313. https://doi.org/10.3390/pharmaceutics16101313

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title = "Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing",

abstract = "Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting method from a combination of polyvinyl alcohol (PVA), Pluronic F127 (PF127), and gum acacia. Results: The successful preparation of the membranes and loading of the extract were confirmed using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The prepared membranes were biodegradable and non-toxic to human skin cells (HaCaT), with high biocompatibility of 92 to 112% cell viability and good hemocompatibility with absorbance ranging from 0.17 to 0.30. The membrane{\textquoteright}s highest water vapor transmission rate was 1654.7333 ± 0.736 g/m2/day and the highest % porosity was 76%. The membranes supported cellular adhesion and migration, with the highest closure being 68% after 4 days compared with the commercial wound dressings. This membrane exhibited enhanced antimicrobial activity against the pathogens responsible for wound infections. Conclusions: The distinct features of the membranes make them promising wound dressings for treating infected wounds.",

keywords = "and membranes, Capparis sepiaria extract, chronic wounds, gum acacia, Pluronic F127, polyvinyl alcohol, propylene glycol, sodium alginate, wound dressing, wounds",

author = "Ndlovu, {Sindi P.} and Motaung, {Keolebogile S.C.M.} and Mapula Razwinani and Sibusiso Alven and Adeyemi, {Samson A.} and Ubanako, {Philemon N.} and Ngema, {Lindokuhle M.} and Fonkui, {Thierry Y.} and Ndinteh, {Derek T.} and Pradeep Kumar and Choonara, {Yahya E.} and Aderibigbe, {Blessing A.}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = oct,

doi = "10.3390/pharmaceutics16101313",

language = "English",

volume = "16",

journal = "Pharmaceutics",

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T1 - Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing

AU - Ndlovu, Sindi P.

AU - Motaung, Keolebogile S.C.M.

AU - Razwinani, Mapula

AU - Alven, Sibusiso

AU - Adeyemi, Samson A.

AU - Ubanako, Philemon N.

AU - Ngema, Lindokuhle M.

AU - Fonkui, Thierry Y.

AU - Ndinteh, Derek T.

AU - Kumar, Pradeep

AU - Choonara, Yahya E.

AU - Aderibigbe, Blessing A.

PY - 2024/10

Y1 - 2024/10

N2 - Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting method from a combination of polyvinyl alcohol (PVA), Pluronic F127 (PF127), and gum acacia. Results: The successful preparation of the membranes and loading of the extract were confirmed using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The prepared membranes were biodegradable and non-toxic to human skin cells (HaCaT), with high biocompatibility of 92 to 112% cell viability and good hemocompatibility with absorbance ranging from 0.17 to 0.30. The membrane’s highest water vapor transmission rate was 1654.7333 ± 0.736 g/m2/day and the highest % porosity was 76%. The membranes supported cellular adhesion and migration, with the highest closure being 68% after 4 days compared with the commercial wound dressings. This membrane exhibited enhanced antimicrobial activity against the pathogens responsible for wound infections. Conclusions: The distinct features of the membranes make them promising wound dressings for treating infected wounds.

AB - Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting method from a combination of polyvinyl alcohol (PVA), Pluronic F127 (PF127), and gum acacia. Results: The successful preparation of the membranes and loading of the extract were confirmed using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The prepared membranes were biodegradable and non-toxic to human skin cells (HaCaT), with high biocompatibility of 92 to 112% cell viability and good hemocompatibility with absorbance ranging from 0.17 to 0.30. The membrane’s highest water vapor transmission rate was 1654.7333 ± 0.736 g/m2/day and the highest % porosity was 76%. The membranes supported cellular adhesion and migration, with the highest closure being 68% after 4 days compared with the commercial wound dressings. This membrane exhibited enhanced antimicrobial activity against the pathogens responsible for wound infections. Conclusions: The distinct features of the membranes make them promising wound dressings for treating infected wounds.

KW - and membranes

KW - Capparis sepiaria extract

KW - chronic wounds

KW - gum acacia

KW - Pluronic F127

KW - polyvinyl alcohol

KW - propylene glycol

KW - sodium alginate

KW - wound dressing

KW - wounds

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DO - 10.3390/pharmaceutics16101313

M3 - Article

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SN - 1999-4923

VL - 16

JO - Pharmaceutics

JF - Pharmaceutics

IS - 10

M1 - 1313

ER -

Capparis sepiaria-Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing

Abstract

Keywords

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