TY - JOUR
T1 - Cancer stem cells in colorectal cancer
T2 - Signaling pathways involved in stemness and therapy resistance
AU - Ebrahimi, Nasim
AU - Afshinpour, Maral
AU - Fakhr, Siavash Seifollahy
AU - Kalkhoran, Paniz Ghasempour
AU - Shadman-Manesh, Vida
AU - Adelian, Samaneh
AU - Beiranvand, Sheida
AU - Rezaei-Tazangi, Fatemeh
AU - Khorram, Roya
AU - Hamblin, Michael R.
AU - Aref, Amir Reza
N1 - Publisher Copyright:
© 2023
PY - 2023/2
Y1 - 2023/2
N2 - Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some cases, treatment can increase patient survival and reduce cancer recurrence, in many cases, tumors can develop resistance to therapy leading to recurrence. One of the main reasons for recurrence and therapy resistance is the presence of cancer stem cells (CSCs). CSCs possess a self-renewal ability, and their stemness properties lead to the avoidance of apoptosis, and allow a new clone of cancer cells to emerge. Numerous investigations inidicated the involvment of cellular signaling pathways in embryonic development, and growth, repair, and maintenance of tissue homeostasis, also participate in the generation and maintenance of stemness in colorectal CSCs. This review discusses the role of Wnt, NF-κB, PI3K/AKT/mTOR, Sonic hedgehog, and Notch signaling pathways in colorectal CSCs, and the possible modulating drugs that could be used in treatment for resistant CRC.
AB - Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some cases, treatment can increase patient survival and reduce cancer recurrence, in many cases, tumors can develop resistance to therapy leading to recurrence. One of the main reasons for recurrence and therapy resistance is the presence of cancer stem cells (CSCs). CSCs possess a self-renewal ability, and their stemness properties lead to the avoidance of apoptosis, and allow a new clone of cancer cells to emerge. Numerous investigations inidicated the involvment of cellular signaling pathways in embryonic development, and growth, repair, and maintenance of tissue homeostasis, also participate in the generation and maintenance of stemness in colorectal CSCs. This review discusses the role of Wnt, NF-κB, PI3K/AKT/mTOR, Sonic hedgehog, and Notch signaling pathways in colorectal CSCs, and the possible modulating drugs that could be used in treatment for resistant CRC.
KW - Cancer initiating cells
KW - Cancer stem cells
KW - Cellular metabolism
KW - Colorectal cancer
KW - Drug resistance
KW - Signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=85146826868&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2023.103920
DO - 10.1016/j.critrevonc.2023.103920
M3 - Review article
C2 - 36702423
AN - SCOPUS:85146826868
SN - 1040-8428
VL - 182
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 103920
ER -
