Can dendritic cells see light?

Aaron C.H. Chen; Ying Ying Huang; Sulbha K. Sharma; Michael R. Hamblin

doi:10.1117/12.842959

Can dendritic cells see light?

Aaron C.H. Chen, Ying Ying Huang, Sulbha K. Sharma, Michael R. Hamblin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

There are many reports showing that low-level light/laser therapy (LLLT) can enhance wound healing, upregulate cell proliferation and has anti-apoptotic effects by activating intracellular protective genes. In the field of immune response study, it is not known with any certainty whether light/laser is proinflammatory or anti-inflammatory. Increasingly in recent times dendritic cells have been found to play an important role in inflammation and the immunological response. In this study, we try to look at the impact of low level near infrared light (810-nm) on murine bone-marrow derived dendritic cells. Changes in surface markers, including MHC II, CD80 and CD11c and the secretion of interleukins induced by light may provide additional evidence to reveal the mystery of how light affects the maturation of dendritic cells as well how these light-induced mature dendritic cells would affect the activation of adaptive immune response.

Original language	English
Title of host publication	Biophotonics and Immune Responses V
DOIs	https://doi.org/10.1117/12.842959
Publication status	Published - 2010
Externally published	Yes
Event	Biophotonics and Immune Responses V - San Francisco, CA, United States Duration: 25 Jan 2010 → 25 Jan 2010

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7565
ISSN (Print)	1605-7422

Conference

Conference	Biophotonics and Immune Responses V
Country/Territory	United States
City	San Francisco, CA
Period	25/01/10 → 25/01/10

Keywords

Bone marrow derived dendritic cells
Confocal microscopy
Flow cytometry
Low level laser therapy
Markers of maturation and activation
Photobiomodulation

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology, Nuclear Medicine and Imaging

Access to Document

10.1117/12.842959

Cite this

@inproceedings{8c751d63d28e4f7bbbcc2284ce42e5cd,

title = "Can dendritic cells see light?",

abstract = "There are many reports showing that low-level light/laser therapy (LLLT) can enhance wound healing, upregulate cell proliferation and has anti-apoptotic effects by activating intracellular protective genes. In the field of immune response study, it is not known with any certainty whether light/laser is proinflammatory or anti-inflammatory. Increasingly in recent times dendritic cells have been found to play an important role in inflammation and the immunological response. In this study, we try to look at the impact of low level near infrared light (810-nm) on murine bone-marrow derived dendritic cells. Changes in surface markers, including MHC II, CD80 and CD11c and the secretion of interleukins induced by light may provide additional evidence to reveal the mystery of how light affects the maturation of dendritic cells as well how these light-induced mature dendritic cells would affect the activation of adaptive immune response.",

keywords = "Bone marrow derived dendritic cells, Confocal microscopy, Flow cytometry, Low level laser therapy, Markers of maturation and activation, Photobiomodulation",

author = "Chen, {Aaron C.H.} and Huang, {Ying Ying} and Sharma, {Sulbha K.} and Hamblin, {Michael R.}",

year = "2010",

doi = "10.1117/12.842959",

language = "English",

isbn = "9780819479617",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Biophotonics and Immune Responses V",

note = "Biophotonics and Immune Responses V ; Conference date: 25-01-2010 Through 25-01-2010",