Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with l-cysteine

Frankline K. Keter; Stephen O. Ojwach; Olayinka A. Oyetunji; Ilia A. Guzei; James Darkwa

doi:10.1016/j.ica.2008.11.030

Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with l-cysteine

Frankline K. Keter, Stephen O. Ojwach, Olayinka A. Oyetunji, Ilia A. Guzei, James Darkwa

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A series of pyrazolyl palladium(II), platinum(II) and gold(III) complexes, [PdCl₂(3,5-R₂bpza)] {R = H (1), R = Me (2), bpza = bis-pyrazolyl acetic acid}, [PtCl₂(3,5-R₂bpza)] {R = H (3a), R = Me (4)}, [AuCl₂(3,5-R₂bpza)]Cl {R = H (5a), R = Me (6a)} and [PdCl₂(3,5-R₂bpzate)] {R = Me (7)} have been synthesised and structurally characterised. Single crystal X-ray crystallography showed that the pyrazolyl ligands exhibit N^N-coordination with the metals. Anticancer activities of six complexes 1-6a were investigated against CHO cells and were found to have low activities. Substitution reactions of selected complexes 1, 2, 3a and 5a with l-cysteine show that the low anticancer activities compounds and that the rate of substitution with sulfur-containing compounds is not the cause of the low anticancer activities.

Original language	English
Pages (from-to)	2595-2602
Number of pages	8
Journal	Inorganica Chimica Acta
Volume	362
Issue number	8
DOIs	https://doi.org/10.1016/j.ica.2008.11.030
Publication status	Published - 1 Jun 2009

Keywords

Bis(pyrazolyl)acetic acid compounds
Cytotoxicity
Pseudo first-order
Substitution
l-cysteine

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ica.2008.11.030

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title = "Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with l-cysteine",

abstract = "A series of pyrazolyl palladium(II), platinum(II) and gold(III) complexes, [PdCl2(3,5-R2bpza)] {R = H (1), R = Me (2), bpza = bis-pyrazolyl acetic acid}, [PtCl2(3,5-R2bpza)] {R = H (3a), R = Me (4)}, [AuCl2(3,5-R2bpza)]Cl {R = H (5a), R = Me (6a)} and [PdCl2(3,5-R2bpzate)] {R = Me (7)} have been synthesised and structurally characterised. Single crystal X-ray crystallography showed that the pyrazolyl ligands exhibit N^N-coordination with the metals. Anticancer activities of six complexes 1-6a were investigated against CHO cells and were found to have low activities. Substitution reactions of selected complexes 1, 2, 3a and 5a with l-cysteine show that the low anticancer activities compounds and that the rate of substitution with sulfur-containing compounds is not the cause of the low anticancer activities.",

keywords = "Bis(pyrazolyl)acetic acid compounds, Cytotoxicity, Pseudo first-order, Substitution, l-cysteine",

author = "Keter, {Frankline K.} and Ojwach, {Stephen O.} and Oyetunji, {Olayinka A.} and Guzei, {Ilia A.} and James Darkwa",

year = "2009",

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doi = "10.1016/j.ica.2008.11.030",

language = "English",

volume = "362",

pages = "2595--2602",

journal = "Inorganica Chimica Acta",

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T1 - Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes

T2 - Syntheses, molecular structures and substitution reactions with l-cysteine

AU - Keter, Frankline K.

AU - Ojwach, Stephen O.

AU - Oyetunji, Olayinka A.

AU - Guzei, Ilia A.

AU - Darkwa, James

PY - 2009/6/1

Y1 - 2009/6/1

N2 - A series of pyrazolyl palladium(II), platinum(II) and gold(III) complexes, [PdCl2(3,5-R2bpza)] {R = H (1), R = Me (2), bpza = bis-pyrazolyl acetic acid}, [PtCl2(3,5-R2bpza)] {R = H (3a), R = Me (4)}, [AuCl2(3,5-R2bpza)]Cl {R = H (5a), R = Me (6a)} and [PdCl2(3,5-R2bpzate)] {R = Me (7)} have been synthesised and structurally characterised. Single crystal X-ray crystallography showed that the pyrazolyl ligands exhibit N^N-coordination with the metals. Anticancer activities of six complexes 1-6a were investigated against CHO cells and were found to have low activities. Substitution reactions of selected complexes 1, 2, 3a and 5a with l-cysteine show that the low anticancer activities compounds and that the rate of substitution with sulfur-containing compounds is not the cause of the low anticancer activities.

AB - A series of pyrazolyl palladium(II), platinum(II) and gold(III) complexes, [PdCl2(3,5-R2bpza)] {R = H (1), R = Me (2), bpza = bis-pyrazolyl acetic acid}, [PtCl2(3,5-R2bpza)] {R = H (3a), R = Me (4)}, [AuCl2(3,5-R2bpza)]Cl {R = H (5a), R = Me (6a)} and [PdCl2(3,5-R2bpzate)] {R = Me (7)} have been synthesised and structurally characterised. Single crystal X-ray crystallography showed that the pyrazolyl ligands exhibit N^N-coordination with the metals. Anticancer activities of six complexes 1-6a were investigated against CHO cells and were found to have low activities. Substitution reactions of selected complexes 1, 2, 3a and 5a with l-cysteine show that the low anticancer activities compounds and that the rate of substitution with sulfur-containing compounds is not the cause of the low anticancer activities.

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KW - Cytotoxicity

KW - Pseudo first-order

KW - Substitution

KW - l-cysteine

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DO - 10.1016/j.ica.2008.11.030

M3 - Article

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SN - 0020-1693

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JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

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ER -

Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with l-cysteine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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