TY - CHAP
T1 - Biphasic Dose–response in Photobiomodulation of Neuronal Cells and the Brain
AU - Salehpour, Farzad
AU - Sadigh-Eteghad, Saeed
AU - Mahmoudi, Javad
AU - Kamari, Farzin
AU - Cassano, Paolo
AU - Hamblin, Michael Richard
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2023
Y1 - 2023
N2 - This chapter examines the biphasic dose-response phenomenon in photobiomodulation (PBM) of neuronal cells and the brain, a critical aspect of understanding and optimizing treatment parameters. The discussion is divided into in vitro and in vivo studies, further exploring the biphasic response in terms of power or irradiance, time or fluence, and treatment sessions. Section 1 introduces the concept of the biphasic dose-response, explaining its significance in PBM research and treatment design. Section 2 focuses on in vitro studies investigating the biphasic dose-response in neuronal cells. It covers the biphasic response in terms of power or irradiance (2.1), time or fluence (2.2), and treatment sessions (2.3), providing a comprehensive understanding of the dose-response relationship in cellular models. Section 3 delves into in vivo studies examining the biphasic dose-response in the brain. The discussion is similarly structured, addressing the biphasic response in terms of power or irradiance (3.1), time or fluence (3.2), and treatment sessions (3.3). Overall, this chapter offers a thorough exploration of the biphasic dose-response in PBM of neuronal cells and the brain, emphasizing the importance of understanding and optimizing treatment parameters to ensure safe and effective therapeutic outcomes.
AB - This chapter examines the biphasic dose-response phenomenon in photobiomodulation (PBM) of neuronal cells and the brain, a critical aspect of understanding and optimizing treatment parameters. The discussion is divided into in vitro and in vivo studies, further exploring the biphasic response in terms of power or irradiance, time or fluence, and treatment sessions. Section 1 introduces the concept of the biphasic dose-response, explaining its significance in PBM research and treatment design. Section 2 focuses on in vitro studies investigating the biphasic dose-response in neuronal cells. It covers the biphasic response in terms of power or irradiance (2.1), time or fluence (2.2), and treatment sessions (2.3), providing a comprehensive understanding of the dose-response relationship in cellular models. Section 3 delves into in vivo studies examining the biphasic dose-response in the brain. The discussion is similarly structured, addressing the biphasic response in terms of power or irradiance (3.1), time or fluence (3.2), and treatment sessions (3.3). Overall, this chapter offers a thorough exploration of the biphasic dose-response in PBM of neuronal cells and the brain, emphasizing the importance of understanding and optimizing treatment parameters to ensure safe and effective therapeutic outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85169002007&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-36231-6_5
DO - 10.1007/978-3-031-36231-6_5
M3 - Chapter
AN - SCOPUS:85169002007
T3 - Synthesis Lectures on Biomedical Engineering
SP - 87
EP - 102
BT - Synthesis Lectures on Biomedical Engineering
PB - Springer Nature
ER -