Biphasic Dose–response in Photobiomodulation of Neuronal Cells and the Brain

Farzad Salehpour, Saeed Sadigh-Eteghad, Javad Mahmoudi, Farzin Kamari, Paolo Cassano, Michael Richard Hamblin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

This chapter examines the biphasic dose-response phenomenon in photobiomodulation (PBM) of neuronal cells and the brain, a critical aspect of understanding and optimizing treatment parameters. The discussion is divided into in vitro and in vivo studies, further exploring the biphasic response in terms of power or irradiance, time or fluence, and treatment sessions. Section 1 introduces the concept of the biphasic dose-response, explaining its significance in PBM research and treatment design. Section 2 focuses on in vitro studies investigating the biphasic dose-response in neuronal cells. It covers the biphasic response in terms of power or irradiance (2.1), time or fluence (2.2), and treatment sessions (2.3), providing a comprehensive understanding of the dose-response relationship in cellular models. Section 3 delves into in vivo studies examining the biphasic dose-response in the brain. The discussion is similarly structured, addressing the biphasic response in terms of power or irradiance (3.1), time or fluence (3.2), and treatment sessions (3.3). Overall, this chapter offers a thorough exploration of the biphasic dose-response in PBM of neuronal cells and the brain, emphasizing the importance of understanding and optimizing treatment parameters to ensure safe and effective therapeutic outcomes.

Original languageEnglish
Title of host publicationSynthesis Lectures on Biomedical Engineering
PublisherSpringer Nature
Pages87-102
Number of pages16
DOIs
Publication statusPublished - 2023

Publication series

NameSynthesis Lectures on Biomedical Engineering
VolumePart F1286
ISSN (Print)1930-0328
ISSN (Electronic)1930-0336

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Biomedical Engineering

Fingerprint

Dive into the research topics of 'Biphasic Dose–response in Photobiomodulation of Neuronal Cells and the Brain'. Together they form a unique fingerprint.

Cite this