Biosynthesis of smaller-sized platinum nanoparticles using the leaf extract of combretum erythrophyllum and its antibacterial activities

Olufunto T. Fanoro, Sundararajan Parani, Rodney Maluleke, Thabang C. Lebepe, Rajendran J. Varghese, Nande Mgedle, Vuyo Mavumengwana, Oluwatobi S. Oluwafemi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Nanobiotechnology is a promising field in the development of safe antibiotics to combat the increasing trend of antibiotic resistance. Nature is a vast reservoir for green materials used in the synthesis of non-toxic and environmentally friendly nano-antibiotics. We present for the first time a facile, green, cost-effective, plant-mediated synthesis of platinum nanoparticles (PtNPs) using the extract of Combretum erythrophyllum (CE) plant leaves. The extract of CE served as both a bio-reductant and a stabilizing agent. The as-synthesized PtNPs were characterized using ultraviolet-visible (UV–Vis) absorption spectroscopy, high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and dynamic light scattering (DLS) techniques. The HR-TEM image confirmed that the PtNPs are ultrasmall, spherical, and well dispersed with an average particle diameter of 1.04 ± 0.26 nm. The PtNPs showed strong antibacterial activities against pathogenic Gram-positive Staphylococcus epidermidis (ATCC 14990) at a minimum inhibitory concentration (MIC) of 3.125 µg/mL and Gram-negative Klebsiella oxytoca (ATCC 8724) and Klebsiella aerogenes (ATCC 27853) at an MIC value of 1.56 µg/mL. The CE-stabilized PtNPs was mostly effective in Klebsiella species that are causative organisms in nosocomial infections.

Original languageEnglish
Article number1275
Issue number11
Publication statusPublished - Nov 2021


  • Antibacterial
  • Combretum erythrophyllum
  • Green synthesis
  • Klebsiella aerogenes
  • Klebsiella oxytoca
  • Platinum nanoparticles

ASJC Scopus subject areas

  • Microbiology
  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics (all)
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)


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