TY - JOUR
T1 - Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated from Rubus fairholmianus Gard.
AU - Plackal George, Blassan
AU - Thangaraj, Parimelazhagan
AU - Sulaiman, Cheruthazhakkatt
AU - Piramanayagam, Shanmughavel
AU - Ramaswamy, Sathish Kumar
N1 - Publisher Copyright:
© 2014 Blassan Plackal George et al.
PY - 2014
Y1 - 2014
N2 - The in vitro and in silico analysis of Rubus fairholmianus acetone extract for antioxidant, antiproliferative, and anti-inflammatory activity led to the isolation of six compounds. Amongst all the six isolated compounds tested, 1-(2-hydroxyphenyl)-4-methylpentan-1-one (compound 1) and 2-[(3-methylbutoxy) carbonyl] benzoic acid (compound 2) were found to be more active in inhibiting BRCA and COX target proteins, which also showed the better results for DPPH and ABTS radical scavenging assays. The promising results of this investigation emphasize the importance of using R. fairholmianus in the treatment of radical generated disorders mainly cancer and other inflammatory diseases.
AB - The in vitro and in silico analysis of Rubus fairholmianus acetone extract for antioxidant, antiproliferative, and anti-inflammatory activity led to the isolation of six compounds. Amongst all the six isolated compounds tested, 1-(2-hydroxyphenyl)-4-methylpentan-1-one (compound 1) and 2-[(3-methylbutoxy) carbonyl] benzoic acid (compound 2) were found to be more active in inhibiting BRCA and COX target proteins, which also showed the better results for DPPH and ABTS radical scavenging assays. The promising results of this investigation emphasize the importance of using R. fairholmianus in the treatment of radical generated disorders mainly cancer and other inflammatory diseases.
UR - http://www.scopus.com/inward/record.url?scp=84930808349&partnerID=8YFLogxK
U2 - 10.1155/2014/204340
DO - 10.1155/2014/204340
M3 - Article
C2 - 25254204
AN - SCOPUS:84930808349
SN - 2314-6133
VL - 2014
JO - BioMed Research International
JF - BioMed Research International
M1 - 204340
ER -
