TY - JOUR
T1 - Autophagy-related MicroRNAs in chronic lung diseases and lung cancer
AU - Rezaei, Samaneh
AU - Mahjoubin-Tehran, Maryam
AU - Aghaee-Bakhtiari, Seyed Hamid
AU - Jalili, Amin
AU - Movahedpour, Ahmad
AU - Khan, Haroon
AU - Moghoofei, Mohsen
AU - Shojaei, Zahra
AU - R Hamblin, Michael
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/9
Y1 - 2020/9
N2 - Chronic lung disease has become a leading cause of death in recent years. Despite several attempts to discover and develop new therapeutic approaches, patients often suffer a poor quality of life, and are faced with an increased risk of developing lung cancer. Lung cancer often occurs as an end-stage after years of chronic lung disease. An increased understanding of the pathophysiology of chronic lung disease may be obtained from studying the role of autophagy in its initiation and progression. MicroRNAs (miRNAs) play a critical role in the modulation of autophagy, and their deregulation could be associated with the initiation and progression of several chronic lung diseases. Herein, we documented that up/down regulation of miRNAs can activate or inhibit autophagy in chronic lung diseases including lung cancer. Therefore, theses miRNAs could be a promising therapeutic tool for lung cancer specially in drug-resistance lung cancer cells.
AB - Chronic lung disease has become a leading cause of death in recent years. Despite several attempts to discover and develop new therapeutic approaches, patients often suffer a poor quality of life, and are faced with an increased risk of developing lung cancer. Lung cancer often occurs as an end-stage after years of chronic lung disease. An increased understanding of the pathophysiology of chronic lung disease may be obtained from studying the role of autophagy in its initiation and progression. MicroRNAs (miRNAs) play a critical role in the modulation of autophagy, and their deregulation could be associated with the initiation and progression of several chronic lung diseases. Herein, we documented that up/down regulation of miRNAs can activate or inhibit autophagy in chronic lung diseases including lung cancer. Therefore, theses miRNAs could be a promising therapeutic tool for lung cancer specially in drug-resistance lung cancer cells.
KW - Autophagy
KW - Chronic obstructive lung disease
KW - Cystic fibrosis
KW - Idiopathic pulmonary fibrosis
KW - Lung cancer
KW - microRNAs
UR - http://www.scopus.com/inward/record.url?scp=85088218407&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2020.103063
DO - 10.1016/j.critrevonc.2020.103063
M3 - Review article
C2 - 32712519
AN - SCOPUS:85088218407
SN - 1040-8428
VL - 153
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 103063
ER -
