Autophagy and gastrointestinal cancers: the behind the scenes role of long non-coding RNAs in initiation, progression, and treatment resistance

Rana Shafabakhsh, Farzaneh Arianfar, Massoud Vosough, Hamid Reza Mirzaei, Maryam Mahjoubin-Tehran, Hashem khanbabaei, Hamed Kowsari, Layla Shojaie, Maryam Ebadi Fard Azar, Michael R. Hamblin, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)

Abstract

Gastrointestinal (GI) cancers comprise a heterogeneous group of complex disorders that affect different organs, including esophagus, stomach, gallbladder, liver, biliary tract, pancreas, small intestine, colon, rectum, and anus. Recently, an explosion in nucleic acid-based technologies has led to the discovery of long non-coding RNAs (lncRNAs) that have been found to possess unique regulatory functions. This class of RNAs is >200 nucleotides in length, and is characterized by their lack of protein coding. LncRNAs exert regulatory effects in GI cancer development by affecting different functions such as the proliferation and metastasis of cancer cells, apoptosis, glycolysis and angiogenesis. Over the past few decades, considerable evidence has revealed the important role of autophagy in both GI cancer progression and suppression. In addition, recent studies have confirmed a significant correlation between lncRNAs and the regulation of autophagy. In this review, we summarize how lncRNAs play a behind the scenes role in the pathogenesis of GI cancers through regulation of autophagy.

Original languageEnglish
Pages (from-to)1229-1255
Number of pages27
JournalCancer Gene Therapy
Volume28
Issue number12
DOIs
Publication statusPublished - Dec 2021

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cancer Research

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