Applications of scaffold-based advanced materials in biomedical sensing

Roya Sarkhosh-Inanlou, Vahid Shafiei-Irannejad, Sajjad Azizi, Abolghasem Jouyban, Jafar Ezzati-Nazhad Dolatabadi, Ahmad Mobed, Bashir Adel, Jafar Soleymani, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


There have been many efforts to synthesize advanced materials that are capable of real-time specific recognition of a molecular target, and allow the quantification of a variety of biomolecules. Scaffold materials have a porous structure, with a high surface area and their intrinsic nanocavities can accommodate cells and macromolecules. The three-dimensional structure (3D) of scaffolds serves not only as a fibrous structure for cell adhesion and growth in tissue engineering, but can also provide the controlled release of drugs and other molecules for biomedical applications. There has been a limited number of reports on the use of scaffold materials in biomedical sensing applications. This review highlights the potential of scaffold materials in the improvement of sensing platforms and summarizes the progress in the application of novel scaffold-based materials as sensor, and discusses their advantages and limitations. Furthermore, the influence of the scaffold materials on the monitoring of infectious diseases such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and bacterial infections, was reviewed.

Original languageEnglish
Article number116342
JournalTrAC - Trends in Analytical Chemistry
Publication statusPublished - Oct 2021


  • Advanced materials
  • Biomedical sensing
  • Disease biomarkers
  • Infectious diseases
  • Scaffold materials
  • Severe acute respiratory syndrome coronavirus

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy


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