TY - JOUR
T1 - Application of Quercetin in the Treatment of Gastrointestinal Cancers
AU - Mirazimi, Seyed Mohammad Ali
AU - Dashti, Fatemeh
AU - Tobeiha, Mohammad
AU - Shahini, Ali
AU - Jafari, Raha
AU - Khoddami, Mehrad
AU - Sheida, Amir Hossein
AU - EsnaAshari, Parastoo
AU - Aflatoonian, Amir Hossein
AU - Elikaii, Fateme
AU - Zakeri, Melika Sadat
AU - Hamblin, Michael R.
AU - Aghajani, Mohammad
AU - Bavarsadkarimi, Minoodokht
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
Copyright © 2022 Mirazimi, Dashti, Tobeiha, Shahini, Jafari, Khoddami, Sheida, EsnaAshari, Aflatoonian, Elikaii, Zakeri, Hamblin, Aghajani, Bavarsadkarimi and Mirzaei.
PY - 2022/4/6
Y1 - 2022/4/6
N2 - Many cellular signaling pathways contribute to the regulation of cell proliferation, division, motility, and apoptosis. Deregulation of these pathways contributes to tumor cell initiation and tumor progression. Lately, significant attention has been focused on the use of natural products as a promising strategy in cancer treatment. Quercetin is a natural flavonol compound widely present in commonly consumed foods. Quercetin has shown significant inhibitory effects on tumor progression via various mechanisms of action. These include stimulating cell cycle arrest or/and apoptosis as well as its antioxidant properties. Herein, we summarize the therapeutic effects of quercetin in gastrointestinal cancers (pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral).
AB - Many cellular signaling pathways contribute to the regulation of cell proliferation, division, motility, and apoptosis. Deregulation of these pathways contributes to tumor cell initiation and tumor progression. Lately, significant attention has been focused on the use of natural products as a promising strategy in cancer treatment. Quercetin is a natural flavonol compound widely present in commonly consumed foods. Quercetin has shown significant inhibitory effects on tumor progression via various mechanisms of action. These include stimulating cell cycle arrest or/and apoptosis as well as its antioxidant properties. Herein, we summarize the therapeutic effects of quercetin in gastrointestinal cancers (pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral).
KW - bioactive compounds
KW - gastrointestinal cancers
KW - natural compounds
KW - quercetin
KW - therapy
UR - http://www.scopus.com/inward/record.url?scp=85128671468&partnerID=8YFLogxK
U2 - 10.3389/fphar.2022.860209
DO - 10.3389/fphar.2022.860209
M3 - Review article
AN - SCOPUS:85128671468
SN - 1663-9812
VL - 13
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 860209
ER -
