Application of P-Bridged Biaryl Phosphines in Pd-Catalyzed α-Arylation Reactions

Malibongwe P. Shandu, Jairus L. Lamola, Cedric W. Holzapfel, Munaka Christopher Maumela, Paseka T. Moshapo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The use of catalysts derived from Pd2(dba)3 and phosphatrioxa-adamantane framework (Cg) has been demonstrated to facilitate the effective alpha(α)-arylation of ketones using a diverse array of aryl halides under mild reaction conditions (40 °C–80 °C). The evaluation of phosphines with dissimilar stereoelectronic properties revealed the pivotal role of fine-tuning the ligand's steric bulk. In particular, catalysts based on the Cg-biphenyl ligand (1) proved efficient for facile α-arylation of electronically and sterically diverse aryl bromides and chlorides.

Original languageEnglish
Article numbere202203712
Issue number41
Publication statusPublished - 7 Nov 2022


  • Biaryl phosphines •
  • Cross-coupling
  • Pd-catalysis
  • Phobane
  • Phosphatrioxa-adamantane
  • α-Arylation

ASJC Scopus subject areas

  • General Chemistry


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