Application of nano-radiosensitizers in combination cancer therapy

Mohammad Varzandeh; Leila Sabouri; Vahid Mansouri; Maliheh Gharibshahian; Nima Beheshtizadeh; Michael R. Hamblin; Nima Rezaei

doi:10.1002/btm2.10498

Application of nano-radiosensitizers in combination cancer therapy

Mohammad Varzandeh
, Leila Sabouri
, Vahid Mansouri
, Maliheh Gharibshahian
, Nima Beheshtizadeh
, Michael R. Hamblin
, Nima Rezaei

Laser Research Centre

Isfahan University of Technology
AmitisGen TECH Dev Group
Universal Scientific Education and Research Network (USERN)
Tehran University of Medical Sciences
School of Medicine

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

Abstract

Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation-induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano-radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects.

Original language	English
Article number	e10498
Journal	Bioengineering and Translational Medicine
Volume	8
Issue number	3
DOIs	https://doi.org/10.1002/btm2.10498
Publication status	Published - May 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer treatment
combination therapy
high-z nanoparticles
oxygen-mimetics
radiosensitizers

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering
Pharmaceutical Science

Access to Document

10.1002/btm2.10498

Cite this

@article{f83fb1021d954acdae0975263590ce45,

title = "Application of nano-radiosensitizers in combination cancer therapy",

abstract = "Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation-induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano-radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects.",

keywords = "cancer treatment, combination therapy, high-z nanoparticles, oxygen-mimetics, radiosensitizers",

author = "Mohammad Varzandeh and Leila Sabouri and Vahid Mansouri and Maliheh Gharibshahian and Nima Beheshtizadeh and Hamblin, \{Michael R.\} and Nima Rezaei",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Bioengineering \& Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.",

year = "2023",

month = may,

doi = "10.1002/btm2.10498",

language = "English",

volume = "8",

journal = "Bioengineering and Translational Medicine",

issn = "2380-6761",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Application of nano-radiosensitizers in combination cancer therapy

AU - Varzandeh, Mohammad

AU - Sabouri, Leila

AU - Mansouri, Vahid

AU - Gharibshahian, Maliheh

AU - Beheshtizadeh, Nima

AU - Hamblin, Michael R.

AU - Rezaei, Nima

PY - 2023/5

Y1 - 2023/5

N2 - Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation-induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano-radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects.

AB - Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation-induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano-radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects.

KW - cancer treatment

KW - combination therapy

KW - high-z nanoparticles

KW - oxygen-mimetics

KW - radiosensitizers

UR - https://www.scopus.com/pages/publications/85147588464

U2 - 10.1002/btm2.10498

DO - 10.1002/btm2.10498

M3 - Review article

AN - SCOPUS:85147588464

SN - 2380-6761

VL - 8

JO - Bioengineering and Translational Medicine

JF - Bioengineering and Translational Medicine

IS - 3

M1 - e10498

ER -

Application of nano-radiosensitizers in combination cancer therapy

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Data on Cancer Detailed by Researchers at Universal Scientific Education and Research Network (Application of Nano-radiosensitizers In Combination Cancer Therapy)

Cite this

Application of nano-radiosensitizers in combination cancer therapy

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Press/Media

Data on Cancer Detailed by Researchers at Universal Scientific Education and Research Network (Application of Nano-radiosensitizers In Combination Cancer Therapy)

Cite this