Application of biopolymer in situ-forming hydrogels in ophthalmic drug delivery system and others

Jonathan Tersur Orasugh, Dipankar Chattopadhyay, Suprakas Sinha Ray, Anjan Adhikari

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

In recent years, the development and utilization of biopolymers in pharmaceutical formulations have gained substantial attention due to their inherent biocompatibility, biodegradability, and low toxicity. This chapter explores the versatile application of biopolymer-based in situ-forming hydrogels in drug delivery systems, with a particular focus on ophthalmic drug delivery. Ophthalmic drug delivery poses unique challenges, including rapid clearance mechanisms, limited drug penetration, and patient compliance issues. Biopolymer-based in situ-forming hydrogels offer promising solutions to these challenges. This chapter provides an in-depth discussion of various biopolymers, such as chitosan, hyaluronic acid, and alginate, and their formulation into hydrogels for ophthalmic drug delivery. By delving into the multifaceted applications of biopolymer-based in situ-forming hydrogels, this chapter aims to provide researchers, scientists, and pharmaceutical professionals with a comprehensive understanding of the potential and challenges associated with these novel drug delivery systems, particularly in the context of ophthalmic drug delivery. Furthermore, it highlights the broader scope of these hydrogels in various therapeutic areas, paving the way for their continued evolution and implementation in the pharmaceutical industry.

Original languageEnglish
Title of host publicationStimuli-Responsive Hydrogels for Ophthalmic Drug Delivery
PublisherElsevier
Pages345-360
Number of pages16
ISBN (Electronic)9780323991568
ISBN (Print)9780323993593
DOIs
Publication statusPublished - 1 Jan 2024

Keywords

  • Biocompatible hydrogels
  • Biodegradable polymers
  • Biopolymer-based hydrogels
  • In situ-forming hydrogels
  • Ophthalmic drug delivery

ASJC Scopus subject areas

  • General Engineering
  • General Materials Science

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