Application of Biaryl Phosphacycles in Palladium-Catalysed Suzuki-Miyaura Cross-Coupling Reactions of Aryl Chlorides

Jairus L. Lamola; Paseka T. Moshapo; Cedric W. Holzapfel; Munaka Christopher Maumela

doi:10.1002/ejic.202400068

Application of Biaryl Phosphacycles in Palladium-Catalysed Suzuki-Miyaura Cross-Coupling Reactions of Aryl Chlorides

Jairus L. Lamola, Paseka T. Moshapo, Cedric W. Holzapfel, Munaka Christopher Maumela

Chemical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The use of Pd-catalysts based on biaryl phosphacycles allowed facile Suzuki-Miyaura couplings of a wide range of deactivated, sterically hindered, and heteroaryl chloride substrates with aryl boronic acids. Notably, the strongly electron-deficient and sufficiently hindered biaryl phosphacycle ligand 7 consistently demonstrated effective performance.

Original language	English
Article number	e202400068
Journal	European Journal of Inorganic Chemistry
Volume	27
Issue number	17
DOIs	https://doi.org/10.1002/ejic.202400068
Publication status	Published - 12 Jun 2024

Keywords

aryl chlorides
biaryl
cross-coupling
electronic
phosphines
steric

ASJC Scopus subject areas

Inorganic Chemistry

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10.1002/ejic.202400068

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title = "Application of Biaryl Phosphacycles in Palladium-Catalysed Suzuki-Miyaura Cross-Coupling Reactions of Aryl Chlorides",

abstract = "The use of Pd-catalysts based on biaryl phosphacycles allowed facile Suzuki-Miyaura couplings of a wide range of deactivated, sterically hindered, and heteroaryl chloride substrates with aryl boronic acids. Notably, the strongly electron-deficient and sufficiently hindered biaryl phosphacycle ligand 7 consistently demonstrated effective performance.",

keywords = "aryl chlorides, biaryl, cross-coupling, electronic, phosphines, steric",

author = "Lamola, {Jairus L.} and Moshapo, {Paseka T.} and Holzapfel, {Cedric W.} and Maumela, {Munaka Christopher}",

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AU - Moshapo, Paseka T.

AU - Holzapfel, Cedric W.

AU - Maumela, Munaka Christopher

PY - 2024/6/12

Y1 - 2024/6/12

N2 - The use of Pd-catalysts based on biaryl phosphacycles allowed facile Suzuki-Miyaura couplings of a wide range of deactivated, sterically hindered, and heteroaryl chloride substrates with aryl boronic acids. Notably, the strongly electron-deficient and sufficiently hindered biaryl phosphacycle ligand 7 consistently demonstrated effective performance.

AB - The use of Pd-catalysts based on biaryl phosphacycles allowed facile Suzuki-Miyaura couplings of a wide range of deactivated, sterically hindered, and heteroaryl chloride substrates with aryl boronic acids. Notably, the strongly electron-deficient and sufficiently hindered biaryl phosphacycle ligand 7 consistently demonstrated effective performance.

KW - aryl chlorides

KW - biaryl

KW - cross-coupling

KW - electronic

KW - phosphines

KW - steric

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DO - 10.1002/ejic.202400068

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JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

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M1 - e202400068

ER -

Application of Biaryl Phosphacycles in Palladium-Catalysed Suzuki-Miyaura Cross-Coupling Reactions of Aryl Chlorides

Abstract

Keywords

ASJC Scopus subject areas

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