Apoptosis and myocardial infarction: role of ncRNAs and exosomal ncRNAs

Alireza Farokhian; Ali Rajabi; Amirhossein Sheida; Amirhossein Abdoli; Moein Rafiei; Zahra Hadian Jazi; Sahar Ahmadi Asouri; Mohammad Amin Morshedi; Michael R. Hamblin; Parisa Adib-Hajbagheri; Hamed Mirzaei

doi:10.2217/epi-2022-0451

Apoptosis and myocardial infarction: role of ncRNAs and exosomal ncRNAs

Alireza Farokhian, Ali Rajabi, Amirhossein Sheida, Amirhossein Abdoli, Moein Rafiei, Zahra Hadian Jazi, Sahar Ahmadi Asouri, Mohammad Amin Morshedi, Michael R. Hamblin, Parisa Adib-Hajbagheri, Hamed Mirzaei

Laser Research Centre

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

ncRNAs, particularly miRNAs, lncRNAs and circRNAs, are a group of RNAs which, although they do not encode proteins (however, recent evidence shows that certain circRNAs are translatable), play a major role in regulating gene expression and, therefore, affect multiple cellular processes, in particular apoptosis. Apoptosis is proven to mediate myocardial infarction physiopathology in addition to ischemic necrosis and, therefore, has recently gained great interest as a target to improve MI outcomes. The current work reviews studies that have assessed ncRNAs with the ability to promote or suppress apoptosis in the process of MI and, therefore, may introduce new therapeutic targets for MI treatment.

Original language	English
Pages (from-to)	307-334
Number of pages	28
Journal	Epigenomics
Volume	15
Issue number	5
DOIs	https://doi.org/10.2217/epi-2022-0451
Publication status	Published - 1 Mar 2023

Keywords

apoptosis
circRNA
exosome
lncRNA
miRNAs
myocardial infarction
ncRNAs

ASJC Scopus subject areas

Genetics
Cancer Research

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10.2217/epi-2022-0451

Cite this

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title = "Apoptosis and myocardial infarction: role of ncRNAs and exosomal ncRNAs",

abstract = "ncRNAs, particularly miRNAs, lncRNAs and circRNAs, are a group of RNAs which, although they do not encode proteins (however, recent evidence shows that certain circRNAs are translatable), play a major role in regulating gene expression and, therefore, affect multiple cellular processes, in particular apoptosis. Apoptosis is proven to mediate myocardial infarction physiopathology in addition to ischemic necrosis and, therefore, has recently gained great interest as a target to improve MI outcomes. The current work reviews studies that have assessed ncRNAs with the ability to promote or suppress apoptosis in the process of MI and, therefore, may introduce new therapeutic targets for MI treatment.",

keywords = "apoptosis, circRNA, exosome, lncRNA, miRNAs, myocardial infarction, ncRNAs",

author = "Alireza Farokhian and Ali Rajabi and Amirhossein Sheida and Amirhossein Abdoli and Moein Rafiei and Jazi, {Zahra Hadian} and Asouri, {Sahar Ahmadi} and Morshedi, {Mohammad Amin} and Hamblin, {Michael R.} and Parisa Adib-Hajbagheri and Hamed Mirzaei",

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TY - JOUR

T1 - Apoptosis and myocardial infarction

T2 - role of ncRNAs and exosomal ncRNAs

AU - Farokhian, Alireza

AU - Rajabi, Ali

AU - Sheida, Amirhossein

AU - Abdoli, Amirhossein

AU - Rafiei, Moein

AU - Jazi, Zahra Hadian

AU - Asouri, Sahar Ahmadi

AU - Morshedi, Mohammad Amin

AU - Hamblin, Michael R.

AU - Adib-Hajbagheri, Parisa

AU - Mirzaei, Hamed

PY - 2023/3/1

Y1 - 2023/3/1

N2 - ncRNAs, particularly miRNAs, lncRNAs and circRNAs, are a group of RNAs which, although they do not encode proteins (however, recent evidence shows that certain circRNAs are translatable), play a major role in regulating gene expression and, therefore, affect multiple cellular processes, in particular apoptosis. Apoptosis is proven to mediate myocardial infarction physiopathology in addition to ischemic necrosis and, therefore, has recently gained great interest as a target to improve MI outcomes. The current work reviews studies that have assessed ncRNAs with the ability to promote or suppress apoptosis in the process of MI and, therefore, may introduce new therapeutic targets for MI treatment.

AB - ncRNAs, particularly miRNAs, lncRNAs and circRNAs, are a group of RNAs which, although they do not encode proteins (however, recent evidence shows that certain circRNAs are translatable), play a major role in regulating gene expression and, therefore, affect multiple cellular processes, in particular apoptosis. Apoptosis is proven to mediate myocardial infarction physiopathology in addition to ischemic necrosis and, therefore, has recently gained great interest as a target to improve MI outcomes. The current work reviews studies that have assessed ncRNAs with the ability to promote or suppress apoptosis in the process of MI and, therefore, may introduce new therapeutic targets for MI treatment.

KW - apoptosis

KW - circRNA

KW - exosome

KW - lncRNA

KW - miRNAs

KW - myocardial infarction

KW - ncRNAs

UR - http://www.scopus.com/inward/record.url?scp=85160876020&partnerID=8YFLogxK

U2 - 10.2217/epi-2022-0451

DO - 10.2217/epi-2022-0451

M3 - Review article

C2 - 37194609

AN - SCOPUS:85160876020

SN - 1750-1911

VL - 15

SP - 307

EP - 334

JO - Epigenomics

JF - Epigenomics

IS - 5

ER -

Apoptosis and myocardial infarction: role of ncRNAs and exosomal ncRNAs

Abstract

Keywords

ASJC Scopus subject areas

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