Antitumor and wound healing properties of rubus niveus thunb. root

Blassan Plackal George, Thangaraj Parimelazhagan, Thankarajan Sajeesh, Shanmugam Saravanan

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The main objective of this study is to highlight the importance of Rubus niveus in the pharmaceutical industry for the development of cost-effective drugs. The study was undertaken to explore the HPLC profile, wound healing, antitumor, and free radical scavenging properties of R. niveus. The root of R. niveus was extracted using organic solvents and subjected to in vitro antioxidant assays. Acetone extract, which showed better in vitro antioxidant properties, was evaluated for in vivo antioxidant, wound healing, and antitumor properties. The polyphenolic acetone extract showed significant in vivo antioxidant, wound healing, and antitumor properties. In the wound healing study, complete epithelialization was noticed during the 13th to 17th days for treated groups. The 250 mg/kg group was found to prolong the life span of mice with Ehrlich ascites carcinoma (70.04%) and reduced the volume of Daltons lymphoma ascites solid tumors (2.07 cm3). The HPLC analysis of acetone extract revealed the presence of Quercetin, a natural flavonoid with the retention time of 20.89 min. The results of the current study suggest the use of R. niveus as a valuable natural antioxidant that has an immense scope as an effective source to cure skin diseases, wounds, and tumors.

Original languageEnglish
Pages (from-to)145-158
Number of pages14
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume33
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Antioxidant
  • Antitumor
  • HPLC
  • Quercetin
  • Rubus niveus
  • Wound healing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

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