Antitumor and Wound Healing Properties of Rubus ellipticus Smith

Blassan Plackal George, Thangaraj Parimelazhagan, Yamini T. Kumar, Thankarajan Sajeesh

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to invitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher invitro antioxidant activity, was taken for the evaluation of invivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of 2g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13th day and the 19th day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton's lymphoma ascite (DLA) solid tumors (2.56cm3). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.

Original languageEnglish
Pages (from-to)134-141
Number of pages8
JournalJAMS Journal of Acupuncture and Meridian Studies
Volume8
Issue number3
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • Antioxidant
  • Antitumor
  • Rubus ellipticus
  • Wound healing

ASJC Scopus subject areas

  • Complementary and Alternative Medicine
  • Anesthesiology and Pain Medicine

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