Antitumor and Wound Healing Properties of Rubus ellipticus Smith

Blassan Plackal George; Thangaraj Parimelazhagan; Yamini T. Kumar; Thankarajan Sajeesh

doi:10.1016/j.jams.2013.10.002

Antitumor and Wound Healing Properties of Rubus ellipticus Smith

Blassan Plackal George, Thangaraj Parimelazhagan, Yamini T. Kumar, Thankarajan Sajeesh

Bharathiar University

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to invitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher invitro antioxidant activity, was taken for the evaluation of invivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of 2g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13^th day and the 19^th day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton's lymphoma ascite (DLA) solid tumors (2.56cm³). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.

Original language	English
Pages (from-to)	134-141
Number of pages	8
Journal	JAMS Journal of Acupuncture and Meridian Studies
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/j.jams.2013.10.002
Publication status	Published - 1 Jun 2015
Externally published	Yes

Keywords

Antioxidant
Antitumor
Rubus ellipticus
Wound healing

ASJC Scopus subject areas

Complementary and Alternative Medicine
Anesthesiology and Pain Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jams.2013.10.002

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title = "Antitumor and Wound Healing Properties of Rubus ellipticus Smith",

abstract = "The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to invitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher invitro antioxidant activity, was taken for the evaluation of invivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of 2g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13th day and the 19th day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton's lymphoma ascite (DLA) solid tumors (2.56cm3). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.",

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AU - Sajeesh, Thankarajan

PY - 2015/6/1

Y1 - 2015/6/1

N2 - The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to invitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher invitro antioxidant activity, was taken for the evaluation of invivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of 2g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13th day and the 19th day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton's lymphoma ascite (DLA) solid tumors (2.56cm3). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.

AB - The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to invitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher invitro antioxidant activity, was taken for the evaluation of invivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of 2g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13th day and the 19th day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton's lymphoma ascite (DLA) solid tumors (2.56cm3). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.

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Antitumor and Wound Healing Properties of Rubus ellipticus Smith

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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