Abstract
The traditional therapeutic indications for the use of Uapaca guineensis (euphorbiaceae) have been investigated. The methanol extract of Uapaca guineensis was evaluated for analgesic effects in animal models. The extract showed significant protective effects against formalin- and acetic acid-induced pain in the mouse. It also produced a significant analgesic activity in pressure-induced pain test and the hot plate test in the rats. The results of the present study suggest that the antinociceptive effect of the methanol extract of Uapaca guineensis may be dependent on central analgesic mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 153-165 |
| Number of pages | 13 |
| Journal | Pharmacologyonline |
| Volume | 3 |
| Publication status | Published - 2007 |
| Externally published | Yes |
Keywords
- Analgesia
- Antinociceptive activity
- Pain
- Uapaca guineensis
- Writhing
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery