Abstract
Photodynamic therapy (PDT) is an alternative treatment for infections that can kill drug resistant bacteria without damaging host-tissue. In this study we used bioluminescent methicillin-resistant Staphylococcus aureus, in a mouse skin abrasion model, to investigate the effect of PDT on bacterial inactivation and wound healing. RLP068/Cl, a tetracationic Zn(II)phthalocyanine derivative and toluidine blue (TBO) were used. The light-dose response of PDT to kill bacteria in vivo and the possible recurrence in the days post-treatment were monitored by real-time bioluminescence imaging, and wound healing by digital photography. The results showed PDT with RLP068/Cl (but not TBO) was able to kill bacteria, to inhibit bacterial re-growth after the treatment and to significantly accelerate the wound healing process.
| Original language | English |
|---|---|
| Pages (from-to) | 733-742 |
| Number of pages | 10 |
| Journal | Journal of Biophotonics |
| Volume | 6 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sept 2013 |
| Externally published | Yes |
Keywords
- Antimicrobial photodynamic therapy
- Cationic zinc phthalocyanine bioluminescence imaging
- Methicillin resistant Staphylococcus aureus
- Skin abrasion
- Skin and soft tissue infection
- Wound healing
ASJC Scopus subject areas
- General Chemistry
- General Materials Science
- General Biochemistry,Genetics and Molecular Biology
- General Engineering
- General Physics and Astronomy
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