Abstract
The relentless advance of drug-resistance among pathogenic microbes, mandates a search for alternative approaches that will not cause resistance. Photodynamic inactivation (PDI) involves the combination of nontoxic dyes with harmless visible light to produce reactive oxygen species that can selectively kill microbial cells. PDI can be broad-spectrum in nature and can also destroy microbial cells in biofilms. Many different kinds of nanoparticles have been studied to potentiate antimicrobial PDI by improving photosensitizer solubility, photochemistry, photophysics and targeting. This review will cover photocatalytic disinfection with titania nanoparticles, carbon nanomaterials (fullerenes, carbon nanotubes and graphene), liposomes and polymeric nanoparticles. Natural polymers (chitosan and cellulose), gold and silver plasmonic nanoparticles, mesoporous silica, magnetic and upconverting nanoparticles have all been used for PDI.
| Original language | English |
|---|---|
| Pages (from-to) | 2379-2404 |
| Number of pages | 26 |
| Journal | Nanomedicine |
| Volume | 10 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 1 Aug 2015 |
| Externally published | Yes |
Keywords
- bacteria
- carbon nanomaterials
- fungi
- liposomes
- photodynamic therapy
- photoinactivation
- photosensitizer
- titania photocatalysis
- upconversion
ASJC Scopus subject areas
- Bioengineering
- Medicine (miscellaneous)
- Biomedical Engineering
- General Materials Science
- Development