Antimicrobial photodynamic inactivation and photodynamic therapy for infections

Liyi Huang, Tianhong Dai, Michael R. Hamblin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

148 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) was initially discovered over 100 years ago by its ability to kill microorganisms, but its use to treat infections clinically has not been much developed. However, the present relentless increase in antibiotic resistance worldwide and the emergence of strains that are resistant to all known antibiotics has stimulated research into novel antimicrobial strategies such as PDT that are thought to be unlikely to lead to the development of resistance. In this chapter we will cover the use of PDT to kill pathogenic microbial cells in vitro and describe a mouse model of localized infection and its treatment by PDT without causing excessive damage to the host tissue.

Original languageEnglish
Title of host publicationPhotodynamic Therapy
Subtitle of host publicationMethods and Protocols
Pages155-173
Number of pages19
DOIs
Publication statusPublished - 2010
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume635
ISSN (Print)1064-3745

Keywords

  • Bacteria
  • Photorhabdus luminescens luciferase
  • antibiotic
  • bioluminescence imaging
  • colony-forming units
  • fungus
  • microbiology
  • mouse model of localized infection
  • wound healing

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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