Antimicrobial comparison on effectiveness of endodontic therapy and endodontic therapy combined with photo-disinfection on patients with periapical lesion: A 6 month follow-up

Aguinaldo S. Garcez, Silvia C. Núñez, Michael R. Hamblin, Martha S. Ribeiro

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Citations (Scopus)

Abstract

This study compares the antimicrobial effect of photodynamic therapy (PDT) combined to endodontic treatment with conventional endodontic treatment alone in patients with necrotic pulp and has a 6-month radiographic follow up comparing the healing of periapical lesions. Fifteen patients with periapical lesion and requiring root canal treatment were selected. Microbiological samples were taken after accessing the root canal, conventional manual endodontic therapy (group 1 n=5) and after accessing the canal, endodontic therapy and PDT (group 2 n=10). All the root canals were filled with a calcium hydroxide paste for 1 week. Radiographs were taken after obturation and following 6 months. Endodontic therapy alone presented an 87% reduction in microorganisms while the combination with PDT had a 95% reduction. Radiographic follow up showed 32% higher reduction in the lesion area in PDT group. Results suggest that the use of PDT added to conventional endodontic treatment leads to a further major reduction of microbial load. PDT is an efficient alternative to chemical antimicrobial agents. It is a non-cumulative local treatment, which may be an appropriate approach for the treatment of infections in the oral cavity.

Original languageEnglish
Title of host publicationMechanisms for Low-Light Therapy III
DOIs
Publication statusPublished - 2008
Externally publishedYes
EventMechanisms for Low-Light Therapy III - San Jose, CA, United States
Duration: 20 Jan 200820 Jan 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6846
ISSN (Print)1605-7422

Conference

ConferenceMechanisms for Low-Light Therapy III
Country/TerritoryUnited States
CitySan Jose, CA
Period20/01/0820/01/08

Keywords

  • Antimicrobial therapy
  • Diode laser
  • Endodontic treatment
  • Low intensity laser therapy
  • Photodinamic therapy
  • Polyethylenimine (PEI) and chlorin(e6)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology, Nuclear Medicine and Imaging

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