Abstract
Lecaniodiscus cupanioides Planch. ex Benth (Order: Sapindales; Family Sapindaceae) is an ethnomedicinal plant that is used as an effective herbal remedy for human diseases and infections in local communities across Africa and Asia. However, its pharmacologically bioactive constituents remain largely unknown. In the present study, extracts from the leaves part of L. cupanioides plant were screened against eleven (11) strains of bacteria by employing microplate broth dilution method. The phytochemical profile of the hexane extract was determined by Gas Chromatography-Mass Spectrometry (GC-MS). The extracts exhibited broad spectrum of antibacterial activities against the tested strains, with minimum inhibitory concentration (MIC) ranging from 0.10-3.33 mg/mL. GC-MS analysis of the extract putatively confirmed the presence 48 phytochemicals which could be responsible for the antibacterial activity. These include phytol, β-citronellol, hexadecanoic acid methyl ester, 1-heptacosanol, and neophytadiene among others. However, it is pertinent to isolate, elucidate and unequivocally evaluate the antibacterial activity of the individual bioactive compound, and elucidate their mechanism of antibacterial actions. According to the literature search and to the best of our knowledge, the phytochemical composition of the leaves extract from L. cupanioides, investigated by GC-MS, was studied for the first time in this study. The current study justifies the clinical traditional uses of L. cupanioides in the management of diseases and infections caused by pathogenic bacteria in Nigerian ethnomedicine.
| Original language | English |
|---|---|
| Pages (from-to) | 914-926 |
| Number of pages | 13 |
| Journal | Pharmacologyonline |
| Volume | 3 |
| Publication status | Published - 30 Dec 2021 |
Keywords
- 1-heptacosanol
- Antibacterial
- Lecaniodiscus cupanioides
- Medicinal plant
- Phytochemicals
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery