TY - JOUR
T1 - Angiogenesis-related non-coding RNAs and gastrointestinal cancer
AU - Razavi, Zahra Sadat
AU - Asgarpour, Kasra
AU - Mahjoubin-Tehran, Maryam
AU - Rasouli, Susan
AU - Khan, Haroon
AU - Shahrzad, Mohammad Karim
AU - Hamblin, Michael R.
AU - Mirzaei, Hamed
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/6/25
Y1 - 2021/6/25
N2 - Gastrointestinal (GI) cancers are among the main reasons for cancer death globally. The deadliest types of GI cancer include colon, stomach, and liver cancers. Multiple lines of evidence have shown that angiogenesis has a key role in the growth and metastasis of all GI tumors. Abnormal angiogenesis also has a critical role in many non-malignant diseases. Therefore, angiogenesis is considered to be an important target for improved cancer treatment. Despite much research, the mechanisms governing angiogenesis are not completely understood. Recently, it has been shown that angiogenesis-related non-coding RNAs (ncRNAs) could affect the development of angiogenesis in cancer cells and tumors. The broad family of ncRNAs, which include long non-coding RNAs, microRNAs, and circular RNAs, are related to the development, promotion, and metastasis of GI cancers, especially in angiogenesis. This review discusses the role of ncRNAs in mediating angiogenesis in various types of GI cancers and looks forward to the introduction of mimetics and antagonists as possible therapeutic agents.
AB - Gastrointestinal (GI) cancers are among the main reasons for cancer death globally. The deadliest types of GI cancer include colon, stomach, and liver cancers. Multiple lines of evidence have shown that angiogenesis has a key role in the growth and metastasis of all GI tumors. Abnormal angiogenesis also has a critical role in many non-malignant diseases. Therefore, angiogenesis is considered to be an important target for improved cancer treatment. Despite much research, the mechanisms governing angiogenesis are not completely understood. Recently, it has been shown that angiogenesis-related non-coding RNAs (ncRNAs) could affect the development of angiogenesis in cancer cells and tumors. The broad family of ncRNAs, which include long non-coding RNAs, microRNAs, and circular RNAs, are related to the development, promotion, and metastasis of GI cancers, especially in angiogenesis. This review discusses the role of ncRNAs in mediating angiogenesis in various types of GI cancers and looks forward to the introduction of mimetics and antagonists as possible therapeutic agents.
KW - angiogenesis
KW - circular RNAs
KW - gastrointestinal cancers
KW - long non-coding RNAs
KW - microRNAs
KW - non-coding RNAs
UR - http://www.scopus.com/inward/record.url?scp=85105802805&partnerID=8YFLogxK
U2 - 10.1016/j.omto.2021.04.002
DO - 10.1016/j.omto.2021.04.002
M3 - Review article
AN - SCOPUS:85105802805
SN - 2372-7705
VL - 21
SP - 220
EP - 241
JO - Molecular Therapy - Oncolytics
JF - Molecular Therapy - Oncolytics
ER -
