An update on fractional picosecond laser treatment: histology and clinical applications

Yanjun Zhou, Michael R. Hamblin, Xiang Wen

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Picosecond lasers have a very short pulse duration and a high peak power density. When fractional optical delivery systems are attached to picosecond lasers, they generate an array of concentrated microspots with a high fluence surrounded by areas with a low fluence. This article discusses the histologic characteristics and clinical applications of fractional picosecond laser treatment. Fractional picosecond laser produces laser-induced optical breakdown (LIOB) and laser-induced cavitation (LIC) in the epidermis and dermis respectively, and can encourage skin regeneration and dermal remodeling. It has been shown that fractional picosecond laser has a positive effect on facial photoaging, enlarged facial pores, dyspigmentation, wrinkles, and atrophic scars. Further research is still needed to confirm the benefits of fractional picosecond lasers.

Original languageEnglish
Article number45
JournalLasers in Medical Science
Issue number1
Publication statusPublished - Dec 2023


  • Clinical applications
  • Fractional optical delivery systems
  • Histologic characteristics
  • Picosecond laser

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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