AMP-activated protein kinase (AMPK) activation by benzofurans and coumestans isolated from erythrina abyssinica

Phi Hung Nguyen; Thi Ngoc Anh Nguyen; Trong Tuan Dao; Hu Won Kang; Derek Tantoh Ndinteh; Joseph Tanyi Mbafor; Won Keun Oh

doi:10.1021/np900745g

AMP-activated protein kinase (AMPK) activation by benzofurans and coumestans isolated from erythrina abyssinica

Phi Hung Nguyen
, Thi Ngoc Anh Nguyen
, Trong Tuan Dao
, Hu Won Kang
, Derek Tantoh Ndinteh
, Joseph Tanyi Mbafor
, Won Keun Oh

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

AMP-activated protein kinase (AMPK) has been proposed as a therapeutic target for the treatment of metabolic syndrome including obesity and type-2 diabetes. The bioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina abyssinica led to the isolation of a new coumestan, erythribyssin N (1), and two new benzofurans, erythribyssin F (2) and erythribyssin H (3), along with five known compounds (4-8). When tested for their stimulatory effects on AMPK activity at a concentration of 10 μM, compounds 4 and 5 showed potent activation, while compounds 1, 2, and 7 had moderate effects. These results suggest that benzofurans and coumestans may be new lead compounds for regulating the AMPK enzyme.

Original language	English
Pages (from-to)	598-602
Number of pages	5
Journal	Journal of Natural Products
Volume	73
Issue number	4
DOIs	https://doi.org/10.1021/np900745g
Publication status	Published - 23 Apr 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and Alternative Medicine
Organic Chemistry

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10.1021/np900745g

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title = "AMP-activated protein kinase (AMPK) activation by benzofurans and coumestans isolated from erythrina abyssinica",

abstract = "AMP-activated protein kinase (AMPK) has been proposed as a therapeutic target for the treatment of metabolic syndrome including obesity and type-2 diabetes. The bioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina abyssinica led to the isolation of a new coumestan, erythribyssin N (1), and two new benzofurans, erythribyssin F (2) and erythribyssin H (3), along with five known compounds (4-8). When tested for their stimulatory effects on AMPK activity at a concentration of 10 μM, compounds 4 and 5 showed potent activation, while compounds 1, 2, and 7 had moderate effects. These results suggest that benzofurans and coumestans may be new lead compounds for regulating the AMPK enzyme.",

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language = "English",

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AU - Nguyen, Phi Hung

AU - Nguyen, Thi Ngoc Anh

AU - Dao, Trong Tuan

AU - Kang, Hu Won

AU - Ndinteh, Derek Tantoh

AU - Mbafor, Joseph Tanyi

AU - Oh, Won Keun

PY - 2010/4/23

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AB - AMP-activated protein kinase (AMPK) has been proposed as a therapeutic target for the treatment of metabolic syndrome including obesity and type-2 diabetes. The bioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina abyssinica led to the isolation of a new coumestan, erythribyssin N (1), and two new benzofurans, erythribyssin F (2) and erythribyssin H (3), along with five known compounds (4-8). When tested for their stimulatory effects on AMPK activity at a concentration of 10 μM, compounds 4 and 5 showed potent activation, while compounds 1, 2, and 7 had moderate effects. These results suggest that benzofurans and coumestans may be new lead compounds for regulating the AMPK enzyme.

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AMP-activated protein kinase (AMPK) activation by benzofurans and coumestans isolated from erythrina abyssinica

Abstract

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ASJC Scopus subject areas

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