Ameliorative potential of Sterculia tragacantha aqueous extract on renal gene expression and biochemical parameters in streptozotocin-induced diabetic rats

Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Precious Ekong Essien, Sunday Amos Onikanni, Oluwafemi Adeleke Ojo, Abidemi Paul Kappo

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Purpose: The ameliorative potential of aqueous leave extract of Sterculia tragacantha on renal gene expression and biochemical parameters in streptozotocin-induced diabetic rats were assessed. Methods: Forty albino rats (out of fifty) were intraperitoneally induced using 35 mg/kg of streptozotocin, and then grouped into normal control, diabetic control, diabetic animals received 150 and 300 mg/kg of aqueous extract of S. tragacantha leaves (AESTL) and diabetic animals placed on 200 mg/kg of metformin. This experiment lasted for two weeks, animals were sacrificed, and a series of biochemical indices were evaluated. Results: Diabetic rats receiving AESTL revealed a momentous decline in fasting blood glucose, urea, creatinine, uric acid, and alkaline phosphatase levels. Administration of AESTL to diabetic animals considerably improved the activities of SOD, CAT, GPx, GST, and GSH with a decline in MDA levels. Also, AESTL reversed abnormalities in mRNA gene expressions of IL-1β, TGF-1β, KIM-1, EPO and CASP 6 in diabetic rats placed on AESTL treatment. The excellent results of diabetic rats maintained on AESTL were supported by histological findings in this study. Conclusion: Hence, AESTL may have beneficial effects in controlling nephropathy associated with diabetes mellitus.

Original languageEnglish
Pages (from-to)103-113
Number of pages11
JournalJournal of Pharmaceutical Investigation
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Anti-nephropathy
  • Diabetic
  • Management
  • mRNA gene expression

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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