Albumin nanostructures as advanced drug delivery systems

Mahdi Karimi, Sajad Bahrami, Soodeh Baghaee Ravari, Parham Sahandi Zangabad, Hamed Mirshekari, Mahnaz Bozorgomid, Somayeh Shahreza, Masume Sori, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

282 Citations (Scopus)

Abstract

Introduction: One of the biggest impacts that the nanotechnology has made on medicine and biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability in biological environments, poor uptake into cells and tissues, sub-optimal selectivity for targets and unwanted side effects. Nanocarriers can be designed as DDSs to overcome many of these drawbacks. One of the most versatile building blocks to prepare these nanocarriers is the ubiquitous, readily available and inexpensive protein, serum albumin. Areas covered: This review covers the use of different types of albumin (human, bovine, rat, and chicken egg) to prepare nanoparticle and microparticle-based structures to bind drugs. Various methods have been used to modify the albumin structure. A range of targeting ligands can be attached to the albumin that can be recognized by specific cell receptors that are expressed on target cells or tissues. Expert opinion: The particular advantages of albumin used in DDSs include ready availability, ease of chemical modification, good biocompatibility, and low immunogenicity. The regulatory approvals that have been received for several albumin-based therapeutic agents suggest that this approach will continue to be successfully explored.

Original languageEnglish
Pages (from-to)1609-1623
Number of pages15
JournalExpert Opinion on Drug Delivery
Volume13
Issue number11
DOIs
Publication statusPublished - 1 Nov 2016
Externally publishedYes

Keywords

  • Human serum albumin
  • bovine serum albumin
  • drug delivery systems
  • nanoparticles
  • ovalbumin

ASJC Scopus subject areas

  • Pharmaceutical Science

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