TY - JOUR
T1 - A simple cycloaddition approach to a racemate of the natural sweetener monatin
AU - Holzapfel, Cedric W.
AU - Bischofberger, Karl
AU - Olivier, Johan
PY - 1994/12/1
Y1 - 1994/12/1
N2 - The reaction of methyl 2-(3-indolylmethyl)-acrylate 2 with carbethoxyformonitrile oxide 3, followed by saponification and reduction, gives mainly racemic monatin 1. Preliminary attempts to adapt the 2+3 cycloaddition to a new chiral synthesis of monatin, is described.
AB - The reaction of methyl 2-(3-indolylmethyl)-acrylate 2 with carbethoxyformonitrile oxide 3, followed by saponification and reduction, gives mainly racemic monatin 1. Preliminary attempts to adapt the 2+3 cycloaddition to a new chiral synthesis of monatin, is described.
UR - http://www.scopus.com/inward/record.url?scp=0028020952&partnerID=8YFLogxK
U2 - 10.1080/00397919408010241
DO - 10.1080/00397919408010241
M3 - Article
AN - SCOPUS:0028020952
SN - 0039-7911
VL - 24
SP - 3197
EP - 3211
JO - Synthetic Communications
JF - Synthetic Communications
IS - 22
ER -