A poly (propylene imine) dendrimer – Carbon nanofiber based aptasensor for bisphenol A in water

Tebogo R. Tsekeli, Tsholofelo I. Sebokolodi, Dimpo S. Sipuka, Foluke O.G. Olorundare, Seyi P. Akanji, Duduzile Nkosi, Omotayo A. Arotiba

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We report a poly (propylene imine) dendrimer-carbon nanofiber nanocomposite (CNFs-PPI) immobilisation platform based aptasensor for bisphenol A (BPA). Amino modified aptamers were immobilised on the CNFs-PPI platform on a glassy carbon electrode (GCE) by covalent bonding using glutaraldehyde as a cross-linker. The interfacial changes on the surface of the electrode during the biosensor fabrication and operation were investigated using electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The proposed aptasensor (GCE/CNFs-PPI/NH-Apt) was able to detect BPA in the range of 1–10 nM, with limits of detection of 0.03 and 0.06 nM obtained from DPV and EIS respectively. The biosensor stability was investigated. Furthermore, the biosensor had good selectivity towards the BPA molecule in the presence of interfering species and exhibited repeatability with a relative standard deviation of 3.8% with good stability. Real sample application of the proposed aptasensor in water samples was investigated and recoveries between 91.8% and 100.3% were obtained.

Original languageEnglish
Article number115783
JournalJournal of Electroanalytical Chemistry
Volume901
DOIs
Publication statusPublished - 15 Nov 2021

Keywords

  • Aptamer
  • Aptasensor
  • Bisphenol A
  • Carbon nanofiber
  • Poly (propylene imine) dendrimer

ASJC Scopus subject areas

  • Analytical Chemistry
  • General Chemical Engineering
  • Electrochemistry

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