A poly (propylene imine) dendrimer – Carbon nanofiber based aptasensor for bisphenol A in water

Tebogo R. Tsekeli; Tsholofelo I. Sebokolodi; Dimpo S. Sipuka; Foluke O.G. Olorundare; Seyi P. Akanji; Duduzile Nkosi; Omotayo A. Arotiba

doi:10.1016/j.jelechem.2021.115783

A poly (propylene imine) dendrimer – Carbon nanofiber based aptasensor for bisphenol A in water

Tebogo R. Tsekeli, Tsholofelo I. Sebokolodi, Dimpo S. Sipuka, Foluke O.G. Olorundare, Seyi P. Akanji, Duduzile Nkosi, Omotayo A. Arotiba

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We report a poly (propylene imine) dendrimer-carbon nanofiber nanocomposite (CNFs-PPI) immobilisation platform based aptasensor for bisphenol A (BPA). Amino modified aptamers were immobilised on the CNFs-PPI platform on a glassy carbon electrode (GCE) by covalent bonding using glutaraldehyde as a cross-linker. The interfacial changes on the surface of the electrode during the biosensor fabrication and operation were investigated using electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The proposed aptasensor (GCE/CNFs-PPI/NH-Apt) was able to detect BPA in the range of 1–10 nM, with limits of detection of 0.03 and 0.06 nM obtained from DPV and EIS respectively. The biosensor stability was investigated. Furthermore, the biosensor had good selectivity towards the BPA molecule in the presence of interfering species and exhibited repeatability with a relative standard deviation of 3.8% with good stability. Real sample application of the proposed aptasensor in water samples was investigated and recoveries between 91.8% and 100.3% were obtained.

Original language	English
Article number	115783
Journal	Journal of Electroanalytical Chemistry
Volume	901
DOIs	https://doi.org/10.1016/j.jelechem.2021.115783
Publication status	Published - 15 Nov 2021

Keywords

Aptamer
Aptasensor
Bisphenol A
Carbon nanofiber
Poly (propylene imine) dendrimer

ASJC Scopus subject areas

Analytical Chemistry
General Chemical Engineering
Electrochemistry

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10.1016/j.jelechem.2021.115783

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title = "A poly (propylene imine) dendrimer – Carbon nanofiber based aptasensor for bisphenol A in water",

abstract = "We report a poly (propylene imine) dendrimer-carbon nanofiber nanocomposite (CNFs-PPI) immobilisation platform based aptasensor for bisphenol A (BPA). Amino modified aptamers were immobilised on the CNFs-PPI platform on a glassy carbon electrode (GCE) by covalent bonding using glutaraldehyde as a cross-linker. The interfacial changes on the surface of the electrode during the biosensor fabrication and operation were investigated using electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The proposed aptasensor (GCE/CNFs-PPI/NH-Apt) was able to detect BPA in the range of 1–10 nM, with limits of detection of 0.03 and 0.06 nM obtained from DPV and EIS respectively. The biosensor stability was investigated. Furthermore, the biosensor had good selectivity towards the BPA molecule in the presence of interfering species and exhibited repeatability with a relative standard deviation of 3.8% with good stability. Real sample application of the proposed aptasensor in water samples was investigated and recoveries between 91.8% and 100.3% were obtained.",

keywords = "Aptamer, Aptasensor, Bisphenol A, Carbon nanofiber, Poly (propylene imine) dendrimer",

author = "Tsekeli, {Tebogo R.} and Sebokolodi, {Tsholofelo I.} and Sipuka, {Dimpo S.} and Olorundare, {Foluke O.G.} and Akanji, {Seyi P.} and Duduzile Nkosi and Arotiba, {Omotayo A.}",

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T1 - A poly (propylene imine) dendrimer – Carbon nanofiber based aptasensor for bisphenol A in water

AU - Tsekeli, Tebogo R.

AU - Sebokolodi, Tsholofelo I.

AU - Sipuka, Dimpo S.

AU - Olorundare, Foluke O.G.

AU - Akanji, Seyi P.

AU - Nkosi, Duduzile

AU - Arotiba, Omotayo A.

PY - 2021/11/15

Y1 - 2021/11/15

N2 - We report a poly (propylene imine) dendrimer-carbon nanofiber nanocomposite (CNFs-PPI) immobilisation platform based aptasensor for bisphenol A (BPA). Amino modified aptamers were immobilised on the CNFs-PPI platform on a glassy carbon electrode (GCE) by covalent bonding using glutaraldehyde as a cross-linker. The interfacial changes on the surface of the electrode during the biosensor fabrication and operation were investigated using electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The proposed aptasensor (GCE/CNFs-PPI/NH-Apt) was able to detect BPA in the range of 1–10 nM, with limits of detection of 0.03 and 0.06 nM obtained from DPV and EIS respectively. The biosensor stability was investigated. Furthermore, the biosensor had good selectivity towards the BPA molecule in the presence of interfering species and exhibited repeatability with a relative standard deviation of 3.8% with good stability. Real sample application of the proposed aptasensor in water samples was investigated and recoveries between 91.8% and 100.3% were obtained.

AB - We report a poly (propylene imine) dendrimer-carbon nanofiber nanocomposite (CNFs-PPI) immobilisation platform based aptasensor for bisphenol A (BPA). Amino modified aptamers were immobilised on the CNFs-PPI platform on a glassy carbon electrode (GCE) by covalent bonding using glutaraldehyde as a cross-linker. The interfacial changes on the surface of the electrode during the biosensor fabrication and operation were investigated using electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The proposed aptasensor (GCE/CNFs-PPI/NH-Apt) was able to detect BPA in the range of 1–10 nM, with limits of detection of 0.03 and 0.06 nM obtained from DPV and EIS respectively. The biosensor stability was investigated. Furthermore, the biosensor had good selectivity towards the BPA molecule in the presence of interfering species and exhibited repeatability with a relative standard deviation of 3.8% with good stability. Real sample application of the proposed aptasensor in water samples was investigated and recoveries between 91.8% and 100.3% were obtained.

KW - Aptamer

KW - Aptasensor

KW - Bisphenol A

KW - Carbon nanofiber

KW - Poly (propylene imine) dendrimer

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A poly (propylene imine) dendrimer – Carbon nanofiber based aptasensor for bisphenol A in water

Abstract

Keywords

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