A perspective review on factors that influence mutagenicity in medicinal plants and their health implications

Medicinal plants are products from natural sources that have found relevance in medicine for several decades. They are rich in bioactive compounds; thus, they are widely used to treat different ailments globally. Medicinal plants have provided hope for the healthcare industry as most are used to synthesize modern medicines currently used in the treatment of various diseases. However, there are still concerns with respect to the mutagenic properties of medicinal plants. Over the years, researchers have embarked on various studies aimed at investigating the mutagenicity of several medicinal plants found in different regions of the world. In this review, we discussed factors that may influence plant mutagenicity and the findings of in vitro and in vivo mutagenicity studies of several medicinal plants from across the globe. In addition, this review considers the potential health implications of mutagenic medicinal plants and safety measures that can be used to mitigate mutagenesis in medicinal plants. To achieve this, we searched for articles reporting on medicinal plants and mutagenesis on the PubMed, Scopus, and Web of Science databases. Several journal articles reported on the mutagenicity of some medicinal plants; however, it was observed that the majority of the articles reported the nonmutagenicity of medicinal plants. The findings from these studies imply that medicinal plants have good prospects in treating diseases and that they are clinically relevant. However, these reports will require further validation to determine their safety for human use as limited in vivo studies were conducted and there are no clinical safety reports for any of the plants discussed in this review.