TY - JOUR
T1 - A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver
AU - Ebuehi, Osaretin A.T.
AU - Erukainure, Ochuko L.
AU - Adione, Rebecca
AU - Oyenihi, Ayodeji B.
N1 - Publisher Copyright:
© 2018, Springer-Verlag London Ltd., part of Springer Nature.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - A novel herbal beverage (HB) was formulated from blends of Moringa oleifera, Dennettia tripetala, and Citrus sinensis and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orally exposed to BLCO (800 mg/kg bodyweight) for 7 days, then treated with HB (200 and 400 mg/kg bodyweight) for another 7 days. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were depleted and elevated respectively in both tissues on exposure to BLCO, which was (p < 0.05) reversed after treatment with HB. Treatment with HB led to significant (p < 0.05) increase in superoxide dismutase (SOD) activities in BLCO-exposed rats. BLCO also caused a significant increase in total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels, while treatment with HB led to significant (p < 0.05) reduced levels. These results thus suggest an ameliorative effect of HB on BLCO-induced oxidative injury in brain and hepatic tissues, which may be attributed to the synergistic effects of the phytochemicals, with quercetin playing a major role.
AB - A novel herbal beverage (HB) was formulated from blends of Moringa oleifera, Dennettia tripetala, and Citrus sinensis and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orally exposed to BLCO (800 mg/kg bodyweight) for 7 days, then treated with HB (200 and 400 mg/kg bodyweight) for another 7 days. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were depleted and elevated respectively in both tissues on exposure to BLCO, which was (p < 0.05) reversed after treatment with HB. Treatment with HB led to significant (p < 0.05) increase in superoxide dismutase (SOD) activities in BLCO-exposed rats. BLCO also caused a significant increase in total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels, while treatment with HB led to significant (p < 0.05) reduced levels. These results thus suggest an ameliorative effect of HB on BLCO-induced oxidative injury in brain and hepatic tissues, which may be attributed to the synergistic effects of the phytochemicals, with quercetin playing a major role.
KW - Antioxidant
KW - Crude oil
KW - Herbal beverage
KW - Oxidative injury
UR - https://www.scopus.com/pages/publications/85045077227
U2 - 10.1007/s00580-018-2654-0
DO - 10.1007/s00580-018-2654-0
M3 - Article
AN - SCOPUS:85045077227
SN - 1618-5641
VL - 27
SP - 699
EP - 704
JO - Comparative Clinical Pathology
JF - Comparative Clinical Pathology
IS - 3
ER -