Abstract
A novel herbal beverage (HB) was formulated from blends of Moringa oleifera, Dennettia tripetala, and Citrus sinensis and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orally exposed to BLCO (800 mg/kg bodyweight) for 7 days, then treated with HB (200 and 400 mg/kg bodyweight) for another 7 days. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were depleted and elevated respectively in both tissues on exposure to BLCO, which was (p < 0.05) reversed after treatment with HB. Treatment with HB led to significant (p < 0.05) increase in superoxide dismutase (SOD) activities in BLCO-exposed rats. BLCO also caused a significant increase in total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels, while treatment with HB led to significant (p < 0.05) reduced levels. These results thus suggest an ameliorative effect of HB on BLCO-induced oxidative injury in brain and hepatic tissues, which may be attributed to the synergistic effects of the phytochemicals, with quercetin playing a major role.
| Original language | English |
|---|---|
| Pages (from-to) | 699-704 |
| Number of pages | 6 |
| Journal | Comparative Clinical Pathology |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 May 2018 |
| Externally published | Yes |
Keywords
- Antioxidant
- Crude oil
- Herbal beverage
- Oxidative injury
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
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