A Multidimensional Group Testing Approach for the Reagent Optimisation of a Suzuki C–C Coupling Reaction

Kariska Potgieter; Elize Smit; Reinout Meijboom

doi:10.1007/s10562-021-03670-0

A Multidimensional Group Testing Approach for the Reagent Optimisation of a Suzuki C–C Coupling Reaction

Kariska Potgieter, Elize Smit, Reinout Meijboom

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A multidimensional group testing approach was utilised for the deconvolution of reagents for a Suzuki cross-coupling reaction. This proof of concept aimed to accelerate the identification of the best reagents for such a reaction. Two deconvolution approaches showed that K₂CO₃, ethanol and benzyldiphenylphosphine were the optimal reagents. With this approach, the optimal reagents are identified faster, and the number of reactions is drastically reduced. Graphical Abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	791-798
Number of pages	8
Journal	Catalysis Letters
Volume	152
Issue number	3
DOIs	https://doi.org/10.1007/s10562-021-03670-0
Publication status	Published - Mar 2022

Keywords

Combinatorial chemistry
Deconvolution
High-throughput
Multidimensional group testing
Suzuki cross-coupling

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1007/s10562-021-03670-0

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title = "A Multidimensional Group Testing Approach for the Reagent Optimisation of a Suzuki C–C Coupling Reaction",

abstract = "A multidimensional group testing approach was utilised for the deconvolution of reagents for a Suzuki cross-coupling reaction. This proof of concept aimed to accelerate the identification of the best reagents for such a reaction. Two deconvolution approaches showed that K2CO3, ethanol and benzyldiphenylphosphine were the optimal reagents. With this approach, the optimal reagents are identified faster, and the number of reactions is drastically reduced. Graphical Abstract: [Figure not available: see fulltext.]",

keywords = "Combinatorial chemistry, Deconvolution, High-throughput, Multidimensional group testing, Suzuki cross-coupling",

author = "Kariska Potgieter and Elize Smit and Reinout Meijboom",

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T1 - A Multidimensional Group Testing Approach for the Reagent Optimisation of a Suzuki C–C Coupling Reaction

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AU - Smit, Elize

AU - Meijboom, Reinout

PY - 2022/3

Y1 - 2022/3

N2 - A multidimensional group testing approach was utilised for the deconvolution of reagents for a Suzuki cross-coupling reaction. This proof of concept aimed to accelerate the identification of the best reagents for such a reaction. Two deconvolution approaches showed that K2CO3, ethanol and benzyldiphenylphosphine were the optimal reagents. With this approach, the optimal reagents are identified faster, and the number of reactions is drastically reduced. Graphical Abstract: [Figure not available: see fulltext.]

AB - A multidimensional group testing approach was utilised for the deconvolution of reagents for a Suzuki cross-coupling reaction. This proof of concept aimed to accelerate the identification of the best reagents for such a reaction. Two deconvolution approaches showed that K2CO3, ethanol and benzyldiphenylphosphine were the optimal reagents. With this approach, the optimal reagents are identified faster, and the number of reactions is drastically reduced. Graphical Abstract: [Figure not available: see fulltext.]

KW - Combinatorial chemistry

KW - Deconvolution

KW - High-throughput

KW - Multidimensional group testing

KW - Suzuki cross-coupling

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ER -

A Multidimensional Group Testing Approach for the Reagent Optimisation of a Suzuki C–C Coupling Reaction

Abstract

Keywords

ASJC Scopus subject areas

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