A model incorporating combined RTIs and PIs therapy during early HIV-1 infection

Sutimin; F. Chirove; E. Soewono; N. Nuraini; L. B. Suromo

doi:10.1016/j.mbs.2017.01.004

A model incorporating combined RTIs and PIs therapy during early HIV-1 infection

Sutimin, F. Chirove, E. Soewono, N. Nuraini, L. B. Suromo

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We develop a within host mathematical model of HIV-1 infection describing the effects of combined RTIs and PIs treatments on early HIV-1 infection when treatment is captured using periodic functions of pharmacokinetics type. We use an alternative of the basic reproduction number to analyze endemicity level of HIV-1 infection. Various treatment scenarios incorporating perfect and imperfect drug adherence in drug administration are explored. Our results show that pharmacokinetics treatment is a more realistic way of administering the treatment. Apart from confirming that PIs drugs are more effective than RTIs drugs and that combined RTIs and PIs therapy is more effective than monotherapy of RTIs or PIs, our results show that imperfect drug adherence leads to the increase of viral in the absence of mutation even though the drug is good.

Original language	English
Pages (from-to)	102-111
Number of pages	10
Journal	Mathematical Biosciences
Volume	285
DOIs	https://doi.org/10.1016/j.mbs.2017.01.004
Publication status	Published - 1 Mar 2017
Externally published	Yes

Keywords

CD4 T cells
Drug efficacy
HIV-1
Langerhans
PIs
RTIs

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mbs.2017.01.004

Cite this

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title = "A model incorporating combined RTIs and PIs therapy during early HIV-1 infection",

abstract = "We develop a within host mathematical model of HIV-1 infection describing the effects of combined RTIs and PIs treatments on early HIV-1 infection when treatment is captured using periodic functions of pharmacokinetics type. We use an alternative of the basic reproduction number to analyze endemicity level of HIV-1 infection. Various treatment scenarios incorporating perfect and imperfect drug adherence in drug administration are explored. Our results show that pharmacokinetics treatment is a more realistic way of administering the treatment. Apart from confirming that PIs drugs are more effective than RTIs drugs and that combined RTIs and PIs therapy is more effective than monotherapy of RTIs or PIs, our results show that imperfect drug adherence leads to the increase of viral in the absence of mutation even though the drug is good.",

keywords = "CD4 T cells, Drug efficacy, HIV-1, Langerhans, PIs, RTIs",

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T1 - A model incorporating combined RTIs and PIs therapy during early HIV-1 infection

AU - Sutimin,

AU - Chirove, F.

AU - Soewono, E.

AU - Nuraini, N.

AU - Suromo, L. B.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - We develop a within host mathematical model of HIV-1 infection describing the effects of combined RTIs and PIs treatments on early HIV-1 infection when treatment is captured using periodic functions of pharmacokinetics type. We use an alternative of the basic reproduction number to analyze endemicity level of HIV-1 infection. Various treatment scenarios incorporating perfect and imperfect drug adherence in drug administration are explored. Our results show that pharmacokinetics treatment is a more realistic way of administering the treatment. Apart from confirming that PIs drugs are more effective than RTIs drugs and that combined RTIs and PIs therapy is more effective than monotherapy of RTIs or PIs, our results show that imperfect drug adherence leads to the increase of viral in the absence of mutation even though the drug is good.

AB - We develop a within host mathematical model of HIV-1 infection describing the effects of combined RTIs and PIs treatments on early HIV-1 infection when treatment is captured using periodic functions of pharmacokinetics type. We use an alternative of the basic reproduction number to analyze endemicity level of HIV-1 infection. Various treatment scenarios incorporating perfect and imperfect drug adherence in drug administration are explored. Our results show that pharmacokinetics treatment is a more realistic way of administering the treatment. Apart from confirming that PIs drugs are more effective than RTIs drugs and that combined RTIs and PIs therapy is more effective than monotherapy of RTIs or PIs, our results show that imperfect drug adherence leads to the increase of viral in the absence of mutation even though the drug is good.

KW - CD4 T cells

KW - Drug efficacy

KW - HIV-1

KW - Langerhans

KW - PIs

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A model incorporating combined RTIs and PIs therapy during early HIV-1 infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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