TY - GEN
T1 - A Hybrid Fuzzy-SVM classifier, applied to gene expression profiling for automated leukaemia diagnosis
AU - Perez, Meir
AU - Rubin, David M.
AU - Scott, Lesley E.
AU - Marwala, Tshilidzi
AU - Stevens, Wendy
PY - 2008
Y1 - 2008
N2 - A Hybrid Fuzzy-SVM classifier, used to automate leukaemia diagnosis based on microarray gene expression data, is presented. A publically available dataset was used to develop and test the classifier. A Fuzzy Gene Filter was developed to select the genes which show significant class variation between various leukaemia types. The results obtained from using all the genes for classification is compared to those obtained when only the top 25 differentiating genes are used. The filtered gene classifier was able to correctly classify the entire test dataset, compared to the unfiltered gene classifier which was only able to achieve an accuracy of 84.2%. The results show that, by reducing dimensionality, classification accuracy is improved since redundant information is excluded, thereby limiting the effect of potential outliers.
AB - A Hybrid Fuzzy-SVM classifier, used to automate leukaemia diagnosis based on microarray gene expression data, is presented. A publically available dataset was used to develop and test the classifier. A Fuzzy Gene Filter was developed to select the genes which show significant class variation between various leukaemia types. The results obtained from using all the genes for classification is compared to those obtained when only the top 25 differentiating genes are used. The filtered gene classifier was able to correctly classify the entire test dataset, compared to the unfiltered gene classifier which was only able to achieve an accuracy of 84.2%. The results show that, by reducing dimensionality, classification accuracy is improved since redundant information is excluded, thereby limiting the effect of potential outliers.
UR - http://www.scopus.com/inward/record.url?scp=62749089325&partnerID=8YFLogxK
U2 - 10.1109/EEEI.2008.4736603
DO - 10.1109/EEEI.2008.4736603
M3 - Conference contribution
AN - SCOPUS:62749089325
SN - 9781424424825
T3 - IEEE Convention of Electrical and Electronics Engineers in Israel, Proceedings
SP - 41
EP - 45
BT - 2008 IEEE 25th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2008
T2 - 2008 IEEE 25th Convention of Electrical and Electronics Engineers in Israel, IEEEI 2008
Y2 - 3 December 2008 through 5 December 2008
ER -
