A fast and benign synthesis of α-aminonitriles by reusable immobilized AlCl3on γ-Al2O3

M. Geeta Pamar, P. Govender, K. Pillay, H. Abrahamse, H. M. Nanjundaswamy

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Reusable, immobilized AlCl3 on γ-Al2O3 is generated by the reaction of AlCl3 on activated γ-Al2O3 of 58 A˚ at 600°C. This is an efficient, catalytic, safe and environmentally acceptable catalyst for the synthesis of a series of α-aminonitriles utilizing Strecker's process by the reaction of carbonyl compounds, amines and trimethylsilyl cyanide (TMSCN) with excellent yields at ambient temperature. The catalyst can be easily recycled and has been reused for thirteen runs without losing its activity.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalIndian Journal of Chemistry - Section B Organic and Medicinal Chemistry
Volume54B
Issue number1
Publication statusPublished - 1 Jan 2015

Keywords

  • Immobilized alcl on γ-alo
  • Reusable catalyst
  • Strecker's reaction
  • α-aminonitriles

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics (all)
  • Organic Chemistry

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