A facile route to 3a,8a-dihydrofuro[2,3-b]benzofurans

Cedric W. Holzapfel, D. Bradley, G. Williams

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Consecutive employment of palladium-catalysis and samanum(II)iodide-induced radical chemistry allows access to analogues of the ABC enol ether tricycle of aflatoxin B1 (1). The Pd-assisted coupling of tubutylstannyl ethers of various 2-iodophenols with 2,5-diacetoxy-2,5-dihydrofuran (4) provided products that could be cyclised into 3a,8a-dihydrofuro [2,3-b]benzofurans using SmI2. Elimination of an acetatosamarium species provides the requisite unsaturation situ.

Original languageEnglish
Pages (from-to)8555-8564
Number of pages10
Issue number31
Publication statusPublished - 31 Jul 1995

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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