A comparison of the toxicity of mono, bis, tris and tetrakis phosphino silver complexes on SNO esophageal cancer cells

Zelinda Engelbrecht; Kariska Potgieter; Zanele Mpela; Rehana Malgas-Enus; Reinout Meijboom; Marianne J. Cronjé

doi:10.2174/1871520617666170522123742

A comparison of the toxicity of mono, bis, tris and tetrakis phosphino silver complexes on SNO esophageal cancer cells

Zelinda Engelbrecht, Kariska Potgieter, Zanele Mpela, Rehana Malgas-Enus, Reinout Meijboom, Marianne J. Cronjé

Chemical Sciences

University of Johannesburg

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background: A broad range of metal-coordinated complexes have been studied for their anticancer activities. However, some of these complexes display high toxicity profiles to non-malignant cells, therefore limiting their use in cancer therapeutics. Aims/Method: Several silver(I) triphenylphosphine adducts were prepared as 1:1 to 1:4 ratios of silver nitrate to triphenylphosphine. They were further used to determine their anticancer activity in a malignant SNO esophageal cell line. The silver(I) phosphine adducts include: [Ag(PPh₃)]NO₃ (1); [Ag(PPh₃)₂]NO₃ (2); [Ag(PPh₃)₃]NO₃ (3) and [Ag(PPh₃)₄]NO₃ (4). In addition, the activity of complexes 1-4 was compared to previously reported complexes [Ag(Ph₂P(CH₂)₂PPh₂)₂]NO₃ (5) and [Ag(Ph₂P(CH₂)₃PPh₂)₂]NO₃ (6). The cytotoxicity of complexes 1-6 was also evaluated in non-malignant human dermal fibroblast cells (HDF-a). Results: The majority of the complexes (specifically those containing PPh₃) were found to be highly toxic to the SNO cells and less toxic towards HDF-a cells, as determined by the alamarBlue® assay. Morphological studies and flow cytometry confirmed that the silver(I) complexes induced apoptosis in the malignant cells. Conclusion: These results may have an impact on research related to drug discovery and silver(I) phosphine complexes could be added to the arsenal of anticancer agents in addition to the silver-bis-diphenylphosphinoethane and silver-bis-diphenylphosphinopropane adducts..

Original language	English
Pages (from-to)	394-400
Number of pages	7
Journal	Anti-Cancer Agents in Medicinal Chemistry
Volume	18
Issue number	3
DOIs	https://doi.org/10.2174/1871520617666170522123742
Publication status	Published - 2018

Keywords

Anticancer activity
Apoptosis
Cytotoxicity
Drug discovery
Esophageal cancer
Silver(I) phosphine complexes

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/1871520617666170522123742

Cite this

@article{27547ae959284c2c87b3cf6fdce3d026,

title = "A comparison of the toxicity of mono, bis, tris and tetrakis phosphino silver complexes on SNO esophageal cancer cells",

abstract = "Background: A broad range of metal-coordinated complexes have been studied for their anticancer activities. However, some of these complexes display high toxicity profiles to non-malignant cells, therefore limiting their use in cancer therapeutics. Aims/Method: Several silver(I) triphenylphosphine adducts were prepared as 1:1 to 1:4 ratios of silver nitrate to triphenylphosphine. They were further used to determine their anticancer activity in a malignant SNO esophageal cell line. The silver(I) phosphine adducts include: [Ag(PPh3)]NO3 (1); [Ag(PPh3)2]NO3 (2); [Ag(PPh3)3]NO3 (3) and [Ag(PPh3)4]NO3 (4). In addition, the activity of complexes 1-4 was compared to previously reported complexes [Ag(Ph2P(CH2)2PPh2)2]NO3 (5) and [Ag(Ph2P(CH2)3PPh2)2]NO3 (6). The cytotoxicity of complexes 1-6 was also evaluated in non-malignant human dermal fibroblast cells (HDF-a). Results: The majority of the complexes (specifically those containing PPh3) were found to be highly toxic to the SNO cells and less toxic towards HDF-a cells, as determined by the alamarBlue{\textregistered} assay. Morphological studies and flow cytometry confirmed that the silver(I) complexes induced apoptosis in the malignant cells. Conclusion: These results may have an impact on research related to drug discovery and silver(I) phosphine complexes could be added to the arsenal of anticancer agents in addition to the silver-bis-diphenylphosphinoethane and silver-bis-diphenylphosphinopropane adducts..",

keywords = "Anticancer activity, Apoptosis, Cytotoxicity, Drug discovery, Esophageal cancer, Silver(I) phosphine complexes",

author = "Zelinda Engelbrecht and Kariska Potgieter and Zanele Mpela and Rehana Malgas-Enus and Reinout Meijboom and Cronj{\'e}, {Marianne J.}",

note = "Publisher Copyright: {\textcopyright} 2018 Bentham Science Publishers.",

year = "2018",

doi = "10.2174/1871520617666170522123742",

language = "English",

volume = "18",

pages = "394--400",

journal = "Anti-Cancer Agents in Medicinal Chemistry",

issn = "1871-5206",

publisher = "Bentham Science Publishers",

number = "3",

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TY - JOUR

T1 - A comparison of the toxicity of mono, bis, tris and tetrakis phosphino silver complexes on SNO esophageal cancer cells

AU - Engelbrecht, Zelinda

AU - Potgieter, Kariska

AU - Mpela, Zanele

AU - Malgas-Enus, Rehana

AU - Meijboom, Reinout

AU - Cronjé, Marianne J.

PY - 2018

Y1 - 2018

N2 - Background: A broad range of metal-coordinated complexes have been studied for their anticancer activities. However, some of these complexes display high toxicity profiles to non-malignant cells, therefore limiting their use in cancer therapeutics. Aims/Method: Several silver(I) triphenylphosphine adducts were prepared as 1:1 to 1:4 ratios of silver nitrate to triphenylphosphine. They were further used to determine their anticancer activity in a malignant SNO esophageal cell line. The silver(I) phosphine adducts include: [Ag(PPh3)]NO3 (1); [Ag(PPh3)2]NO3 (2); [Ag(PPh3)3]NO3 (3) and [Ag(PPh3)4]NO3 (4). In addition, the activity of complexes 1-4 was compared to previously reported complexes [Ag(Ph2P(CH2)2PPh2)2]NO3 (5) and [Ag(Ph2P(CH2)3PPh2)2]NO3 (6). The cytotoxicity of complexes 1-6 was also evaluated in non-malignant human dermal fibroblast cells (HDF-a). Results: The majority of the complexes (specifically those containing PPh3) were found to be highly toxic to the SNO cells and less toxic towards HDF-a cells, as determined by the alamarBlue® assay. Morphological studies and flow cytometry confirmed that the silver(I) complexes induced apoptosis in the malignant cells. Conclusion: These results may have an impact on research related to drug discovery and silver(I) phosphine complexes could be added to the arsenal of anticancer agents in addition to the silver-bis-diphenylphosphinoethane and silver-bis-diphenylphosphinopropane adducts..

AB - Background: A broad range of metal-coordinated complexes have been studied for their anticancer activities. However, some of these complexes display high toxicity profiles to non-malignant cells, therefore limiting their use in cancer therapeutics. Aims/Method: Several silver(I) triphenylphosphine adducts were prepared as 1:1 to 1:4 ratios of silver nitrate to triphenylphosphine. They were further used to determine their anticancer activity in a malignant SNO esophageal cell line. The silver(I) phosphine adducts include: [Ag(PPh3)]NO3 (1); [Ag(PPh3)2]NO3 (2); [Ag(PPh3)3]NO3 (3) and [Ag(PPh3)4]NO3 (4). In addition, the activity of complexes 1-4 was compared to previously reported complexes [Ag(Ph2P(CH2)2PPh2)2]NO3 (5) and [Ag(Ph2P(CH2)3PPh2)2]NO3 (6). The cytotoxicity of complexes 1-6 was also evaluated in non-malignant human dermal fibroblast cells (HDF-a). Results: The majority of the complexes (specifically those containing PPh3) were found to be highly toxic to the SNO cells and less toxic towards HDF-a cells, as determined by the alamarBlue® assay. Morphological studies and flow cytometry confirmed that the silver(I) complexes induced apoptosis in the malignant cells. Conclusion: These results may have an impact on research related to drug discovery and silver(I) phosphine complexes could be added to the arsenal of anticancer agents in addition to the silver-bis-diphenylphosphinoethane and silver-bis-diphenylphosphinopropane adducts..

KW - Anticancer activity

KW - Apoptosis

KW - Cytotoxicity

KW - Drug discovery

KW - Esophageal cancer

KW - Silver(I) phosphine complexes

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U2 - 10.2174/1871520617666170522123742

DO - 10.2174/1871520617666170522123742

M3 - Article

C2 - 28530542

AN - SCOPUS:85044281174

SN - 1871-5206

VL - 18

SP - 394

EP - 400

JO - Anti-Cancer Agents in Medicinal Chemistry

JF - Anti-Cancer Agents in Medicinal Chemistry

IS - 3

ER -

A comparison of the toxicity of mono, bis, tris and tetrakis phosphino silver complexes on SNO esophageal cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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