A colorimetric chemosensor for distinct color change with (E)-2-(1-(3-aminophenyl)ethylideneamino)benzenethiol to detect Cu2+ in real water samples

Nilima Patil, R. B. Dhake, Raju Phalak, Umesh Fegade, Inamuddin, Mu Naushad, Chinna Bathula, Suvardhan Kanchi, Krishna Govender

Research output: Contribution to journalArticlepeer-review


The study reports the synthesis of chemosensor (E)-2-(1-(3-aminophenyl)ethylideneamino)benzenethiol (C1), a highly sensitive, colorimetric metal probe that shows distinct selectivity for the detection of Cu2+ ion in various real water samples. Upon complexation with Cu2+ in CH3OH/H2O (60:40 v/v) (aqueous methanol), the C1 demonstrate significant enhancement in the absorption at 250 nm and 300 nm with a color change from light yellow to brown which was visualized using naked-eye. Therefore, these properties make C1 as an effective candidate for on-site Cu2+ ions detection. The emission spectrum of C1 illustrated “TURN-ON” recognition of Cu2+ with a limit of detection (LOD) of 46 nM. Furthermore, Density Functional Theory (DFT) calculations were performed to better understand the interactions between C1 and Cu2+. The obtained results suggested that the electron clouds present around the –NH2 in nitrogen and sulfur in –SH play a pivotal role in the formation of a stable complex. The computational results were in good agreement with the experimental UV–visible spectrometry results. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1413-1423
Number of pages11
JournalAnalytical Sciences
Issue number8
Publication statusPublished - Aug 2023


  • Chemosensor
  • Colorimetry
  • DFT studies
  • Schiff base
  • Water samples

ASJC Scopus subject areas

  • Analytical Chemistry


Dive into the research topics of 'A colorimetric chemosensor for distinct color change with (E)-2-(1-(3-aminophenyl)ethylideneamino)benzenethiol to detect Cu2+ in real water samples'. Together they form a unique fingerprint.

Cite this