4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside; a potential anti-diabetic agent

Samson Oluwaseyi Famuyiwa; Kolade Olatubosun Faloye; Marcus Durojaiye Ayoola; Emmanuel Gabriel Fakola; Derek Tantoh Ndinteh

doi:10.1016/j.rechem.2022.100644

4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside; a potential anti-diabetic agent

Samson Oluwaseyi Famuyiwa, Kolade Olatubosun Faloye, Marcus Durojaiye Ayoola, Emmanuel Gabriel Fakola, Derek Tantoh Ndinteh

Chemical Sciences

Obafemi Awolowo University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The search for phytochemicals for their pharmacological effects cannot be over emphasized. 4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside (GEP) was isolated from the stem bark of Terminalia superba. The structural elucidation was carried out using spectroscopic techniques; IR, ¹H-, ¹³C-, Dept135- and 2D NMR, and MS. Hypoglycaemic and antidiabetic activities of the isolated compound were carried out in normal and streptozotocin induced diabetic rats. The compound demonstrated better hypoglycemia and antidiabetic activities as against the reference compound, glibenclamide at tested doses. The DFT study of the isolated compound and the reference compound was carried out using the B3YLP model. And the results obtained in the DFT study complement the experimental.

Original language	English
Article number	100644
Journal	Results in Chemistry
Volume	4
DOIs	https://doi.org/10.1016/j.rechem.2022.100644
Publication status	Published - Jan 2022

Keywords

4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside
Antidiabetic
Glibenclamide
Hypoglycemia

ASJC Scopus subject areas

General Chemistry

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10.1016/j.rechem.2022.100644

Cite this

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title = "4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside; a potential anti-diabetic agent",

abstract = "The search for phytochemicals for their pharmacological effects cannot be over emphasized. 4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside (GEP) was isolated from the stem bark of Terminalia superba. The structural elucidation was carried out using spectroscopic techniques; IR, 1H-, 13C-, Dept135- and 2D NMR, and MS. Hypoglycaemic and antidiabetic activities of the isolated compound were carried out in normal and streptozotocin induced diabetic rats. The compound demonstrated better hypoglycemia and antidiabetic activities as against the reference compound, glibenclamide at tested doses. The DFT study of the isolated compound and the reference compound was carried out using the B3YLP model. And the results obtained in the DFT study complement the experimental.",

keywords = "4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside, Antidiabetic, Glibenclamide, Hypoglycemia",

author = "{Oluwaseyi Famuyiwa}, Samson and {Olatubosun Faloye}, Kolade and {Durojaiye Ayoola}, Marcus and {Gabriel Fakola}, Emmanuel and {Tantoh Ndinteh}, Derek",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = jan,

doi = "10.1016/j.rechem.2022.100644",

language = "English",

volume = "4",

journal = "Results in Chemistry",

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publisher = "Elsevier B.V.",

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AU - Oluwaseyi Famuyiwa, Samson

AU - Olatubosun Faloye, Kolade

AU - Durojaiye Ayoola, Marcus

AU - Gabriel Fakola, Emmanuel

AU - Tantoh Ndinteh, Derek

PY - 2022/1

Y1 - 2022/1

N2 - The search for phytochemicals for their pharmacological effects cannot be over emphasized. 4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside (GEP) was isolated from the stem bark of Terminalia superba. The structural elucidation was carried out using spectroscopic techniques; IR, 1H-, 13C-, Dept135- and 2D NMR, and MS. Hypoglycaemic and antidiabetic activities of the isolated compound were carried out in normal and streptozotocin induced diabetic rats. The compound demonstrated better hypoglycemia and antidiabetic activities as against the reference compound, glibenclamide at tested doses. The DFT study of the isolated compound and the reference compound was carried out using the B3YLP model. And the results obtained in the DFT study complement the experimental.

AB - The search for phytochemicals for their pharmacological effects cannot be over emphasized. 4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside (GEP) was isolated from the stem bark of Terminalia superba. The structural elucidation was carried out using spectroscopic techniques; IR, 1H-, 13C-, Dept135- and 2D NMR, and MS. Hypoglycaemic and antidiabetic activities of the isolated compound were carried out in normal and streptozotocin induced diabetic rats. The compound demonstrated better hypoglycemia and antidiabetic activities as against the reference compound, glibenclamide at tested doses. The DFT study of the isolated compound and the reference compound was carried out using the B3YLP model. And the results obtained in the DFT study complement the experimental.

KW - 4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside

KW - Antidiabetic

KW - Glibenclamide

KW - Hypoglycemia

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ER -

4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside; a potential anti-diabetic agent

Abstract

Keywords

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Research from Obafemi Awolowo University Provide New Insights into Chemistry (4'-O-galloy-3,3'-di-O-methylellargic acid 4-O-xylopyranoside; a potential anti-diabetic agent)

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4′-O-galloy-3,3′-di-O-methylellargic acid 4-O-xylopyranoside; a potential anti-diabetic agent

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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Research from Obafemi Awolowo University Provide New Insights into Chemistry (4'-O-galloy-3,3'-di-O-methylellargic acid 4-O-xylopyranoside; a potential anti-diabetic agent)

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