α-Glucosidase, α-amylase inhibition kinetics, in vitro gastro-intestinal digestion, and apoptosis inducing abilities of Ficus microcarpa L. f. and Ficus racemosa L. fruit polysaccharides

Kasipandi Muniyandi, Gayathri Jagadeesan, Blassan P. George, Ashwini Lydia Manoharan, Gayathri Nataraj, Heidi Abrahamse, Parimelazhagan Thangaraj

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A rich source of nutrients, figs have a number of clinically validated benefits. This study aimed to evaluate the in vitro simulated gastrointestinal digestion, and the antidiabetic and anticancer activity of Ficus microcarpa (FMP) and F. racemosa (FRP) fruits polysaccharides. The pre-digested FMP revealed higher sugar content (721 ± 14.81 mg glucose equivalents/g sample) than FRP. After in vitro digestion, isolated fruit polysaccharides showed effective uptake with over 80% sugar loss. Free radicals and enzymatic inhibition after gastric digestion have been significantly modified, demonstrating the effective absorption of FMP and FRP through the intestine. Conversely, after the continuous digestion, the nutritional content of the isolated polysaccharides was gradually decreased compared to the pre-digested sample. At 30 µg/mL concentration of FMP and FRP was inhibited by 50% of breast cancer cells. The present study reveals the potential uptake of FMP and FRP as nutritional supplements in the future. Graphical abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)1717-1728
Number of pages12
JournalFood Science and Biotechnology
Volume31
Issue number13
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Antioxidant
  • Apoptosis
  • Cancer
  • Fig
  • α-Amylase
  • α-Glucosidase

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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