TY - JOUR
T1 - α-Glucosidase, α-amylase inhibition kinetics, in vitro gastro-intestinal digestion, and apoptosis inducing abilities of Ficus microcarpa L. f. and Ficus racemosa L. fruit polysaccharides
AU - Muniyandi, Kasipandi
AU - Jagadeesan, Gayathri
AU - George, Blassan P.
AU - Manoharan, Ashwini Lydia
AU - Nataraj, Gayathri
AU - Abrahamse, Heidi
AU - Thangaraj, Parimelazhagan
N1 - Publisher Copyright:
© 2022, The Korean Society of Food Science and Technology.
PY - 2022/12
Y1 - 2022/12
N2 - A rich source of nutrients, figs have a number of clinically validated benefits. This study aimed to evaluate the in vitro simulated gastrointestinal digestion, and the antidiabetic and anticancer activity of Ficus microcarpa (FMP) and F. racemosa (FRP) fruits polysaccharides. The pre-digested FMP revealed higher sugar content (721 ± 14.81 mg glucose equivalents/g sample) than FRP. After in vitro digestion, isolated fruit polysaccharides showed effective uptake with over 80% sugar loss. Free radicals and enzymatic inhibition after gastric digestion have been significantly modified, demonstrating the effective absorption of FMP and FRP through the intestine. Conversely, after the continuous digestion, the nutritional content of the isolated polysaccharides was gradually decreased compared to the pre-digested sample. At 30 µg/mL concentration of FMP and FRP was inhibited by 50% of breast cancer cells. The present study reveals the potential uptake of FMP and FRP as nutritional supplements in the future. Graphical abstract: [Figure not available: see fulltext.].
AB - A rich source of nutrients, figs have a number of clinically validated benefits. This study aimed to evaluate the in vitro simulated gastrointestinal digestion, and the antidiabetic and anticancer activity of Ficus microcarpa (FMP) and F. racemosa (FRP) fruits polysaccharides. The pre-digested FMP revealed higher sugar content (721 ± 14.81 mg glucose equivalents/g sample) than FRP. After in vitro digestion, isolated fruit polysaccharides showed effective uptake with over 80% sugar loss. Free radicals and enzymatic inhibition after gastric digestion have been significantly modified, demonstrating the effective absorption of FMP and FRP through the intestine. Conversely, after the continuous digestion, the nutritional content of the isolated polysaccharides was gradually decreased compared to the pre-digested sample. At 30 µg/mL concentration of FMP and FRP was inhibited by 50% of breast cancer cells. The present study reveals the potential uptake of FMP and FRP as nutritional supplements in the future. Graphical abstract: [Figure not available: see fulltext.].
KW - Antioxidant
KW - Apoptosis
KW - Cancer
KW - Fig
KW - α-Amylase
KW - α-Glucosidase
UR - http://www.scopus.com/inward/record.url?scp=85138200411&partnerID=8YFLogxK
U2 - 10.1007/s10068-022-01162-4
DO - 10.1007/s10068-022-01162-4
M3 - Article
AN - SCOPUS:85138200411
SN - 1226-7708
VL - 31
SP - 1717
EP - 1728
JO - Food Science and Biotechnology
JF - Food Science and Biotechnology
IS - 13
ER -
